{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:18:28Z","timestamp":1791119908780,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the impact of dysphagia on long\u2010term survival and swallowing function outcomes in patients with idiopathic inflammatory myopathy other than inclusion body myositis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated consecutive patients with idiopathic inflammatory myopathy other than inclusion body myositis to investigate the impact of dysphagia and its severity assessed using the Food Intake LEVEL Scale on survival and swallowing function outcomes. Time\u2010to\u2010event analyses were used, including Kaplan\u2010Meier curves with log\u2010rank (trend) test, cumulative incidence with Gray\u2019s test, and Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 254 patients, 26 were dysphagic, including eight severe (Food Intake LEVEL Scale [FILS] score 2, 3) and six most severe (FILS score 1) cases; 210 were non\u2010dysphagic, and 18 were indeterminate cases. During the 5\u2009years after myositis diagnosis, 15 (57.7%) dysphagic and 31 (14.8%) non\u2010dysphagic patients died, and dysphagic patients had significantly shorter survival. However, multivariate analysis showed that shorter survival was significantly associated with baseline age\u2010adjusted Charlson Comorbidity Index (hazard ratio [HR] 1.57, 95% confidence interval [CI] 1.36\u20101.82]), but not with dysphagia (HR 1.46, 95% CI 0.69\u20103.10). Dysphagia severity was significantly associated with delayed recovery of dysphagia. In 20 non\u2010severe or severe dysphagic cases, 19 restored swallowing function within 1\u2009year. The most severe cases had a significantly higher cumulative probability of death before recovery from dysphagia than severe cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The poor survival of dysphagic myositis patients was largely confounded by advanced age and comorbid malignancies. However, patients with the most severe dysphagia had a significantly worse swallowing function and survival prognosis than those with milder dysphagia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14365","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T07:13:48Z","timestamp":1654758828000},"page":"897-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of dysphagia and its severity on long\u2010term survival and swallowing function outcomes in patients with idiopathic inflammatory myopathies other than inclusion body myositis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8651-4149","authenticated-orcid":false,"given":"Shin\u2010ichiro","family":"Ohmura","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Nagoya City University Hospital, and Department of Respiratory Medicine, 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