{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:15:39Z","timestamp":1776129339737,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study describes the characteristics of vertebral osteophytes in different inflammatory and non\u2010inflammatory diseases aiming to reflect the aortic\u2010vertebrae interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study including 4 group of patients, ankylosing spondylitis (AS, n\u00a0=\u00a052), Takayasu's arteritis (TKA, n\u00a0=\u00a031), diffuse idiopathic skeletal hyperostosis (DISH, n\u00a0=\u00a030), coronary artery disease (CAD, n\u00a0=\u00a010), 100 and also age\u2010matched healthy controls (HC, n\u00a0=\u00a0143). All subjects underwent a chest computed tomography scan and images of the upper and lower border of 7 adjacent thoracic vertebrae (T5 to T12) were captured. An \u201caorta ipsilateral ratio\u201d (AIR) of the osteophyte was calculated as the area across the midline toward the aorta side divided by the total osteophyte area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of subjects with osteophytes and osteophyte counts increased with age across the board. Frequencies of osteophytes in AS and TKA were much higher than age\u2010matched HCs. The AIRs were significantly elevated in AS, TKA and CAD compared with DISH or age\u2010matched HCs. In addition, the AIR of patients with higher C\u2010reactive protein levels (&gt;8\u00a0mg\/L) were greater than those with lower levels, both among AS and CAD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that, in an inflammatory niche, regardless of the origin or the grade of the inflammation, ossification will be facilitated and screwed toward the aorta. There is a possible mechanistic connection between large vessel and new bone formation in the context of inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14366","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T07:05:44Z","timestamp":1655103944000},"page":"910-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inflammation, new bone formation and aorta"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-1853","authenticated-orcid":false,"given":"Jie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai JiaoTong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai JiaoTong University School 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