{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:39:37Z","timestamp":1788316777426,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/00006\u20107"],"award-info":[{"award-number":["2016\/00006\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/01315\u20109"],"award-info":[{"award-number":["2018\/01315\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate hand function by hand grip test in rheumatoid arthritis (RA) patients, and its association with bone erosions and the estimated bone strength (finite element \u2013 FE analysis) through the analysis of the 2nd metacarpal head of the dominant hand using high resolution peripheral quantitative computed tomography (HR\u2010pQCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eighty\u2010two female RA patients between 18\u201050\u2009years old were selected. Demographic data, Health Questionnaire Assessment Disability Index (HAQ), Disease Activity Score of 28 joints (DAS)\u201028, simplified disease activity index (SDAI) and the hand grip test were set. The HR\u2010pQCT scans of 2nd metacarpophalangeal joints of the dominant hand of all patients were performed according to SPECTRA group protocols. The images were used to assess bone erosions and FE analysis. The hand grip test was categorized in 2 groups and separately compared (&lt;\u200918 vs \u226518\u2009kgf). A logistic regression was performed using hand grip test &lt;18\u2009kgf as a dependent variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant difference was found between the 2 groups regarding HAQ, inflammatory markers (erythrocyte sedimentation rate, C\u2010reactive protein), DAS\u201028, SDAI, total volume of erosion and bone strength parameter (FE analysis \u2013 Failure Load [F.Load]). The logistic regression analysis showed that the risk factors associated with hand grip test &lt;18\u2009kgf were higher SDAI (odds ratio [OR] 0.912; 95% CI 0.837\u20100.993) and lower values of bone strength parameter (F.Load) (OR 1.007; 95% CI 1.002\u20101.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lower values of hand grip test were associated with higher disease activity score\u2010SDAI and lower bone strength of 2nd metacarpal bone head of the dominant hand evaluated here through a FE analysis using HR\u2010pQCT scan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14376","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T09:56:14Z","timestamp":1656496574000},"page":"1038-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lower hand grip in rheumatoid arthritis patients is associated with low finite element analysis using high resolution peripheral quantitative computed tomography scan of the 2nd metacarpophalangeal joint"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-8175","authenticated-orcid":false,"given":"Camille Pinto","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Bone Metabolism Laboratory, Rheumatology Division Faculdade de Medicina FMUSP Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Ortega","family":"Perez","sequence":"additional","affiliation":[{"name":"Bone Metabolism Laboratory, Rheumatology Division Faculdade de Medicina FMUSP Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Peixoto","family":"Sales","sequence":"additional","affiliation":[{"name":"Bone Metabolism Laboratory, Rheumatology Division Faculdade de Medicina FMUSP Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Souza","family":"Domiciano","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Sao Paulo HCFMUSP  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia M.","family":"Sampaio\u2010Barros","sequence":"additional","affiliation":[{"name":"Bone Metabolism Laboratory, Rheumatology Division Faculdade de Medicina FMUSP Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria de Falco","family":"Caparbo","sequence":"additional","affiliation":[{"name":"Bone Metabolism Laboratory, Rheumatology Division Faculdade de Medicina FMUSP Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria Rodrigues","family":"Pereira","sequence":"additional","affiliation":[{"name":"Bone Metabolism Laboratory, Rheumatology Division Faculdade 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