{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:52:37Z","timestamp":1790142757904,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773514"],"award-info":[{"award-number":["81773514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073655"],"award-info":[{"award-number":["82073655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The causal relationship between common mineral nutrients and ankylosing spondylitis (AS) has not been studied. So this Mendelian randomization (MR) study aims to investigate the causal association of varying levels of calcium, zinc, copper, and selenium on AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We selected 4 elements potentially associated with the onset and development of AS as exposure factors, single nucleotide polymorphisms (SNPs) as instrumental variables, and these SNPs are independent of each other(<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009&lt;\u20090.05) and highly correlated with each of the 4 elements (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>). The 2\u2010sample MR method takes Inverse\u2010variance weighted (IVW) and MR\u2010Egger as the main method and Simple mode (SM), Weighted median (WM<jats:sup>1<\/jats:sup>), and Weighted mode (WM<jats:sup>2<\/jats:sup>) as supplementary methods to evaluate the causal effect of mineral levels on AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IVW analysis does not provide convincing evidence to support a causal association between calcium (odds ratio [OR]\u00a0=\u00a01.000, 95% CI\u00a0=\u00a00.994, 1.005,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.875), copper (OR\u00a0=\u00a01.000, 95% CI\u00a0=\u00a01.000, 1.001,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.533) and selenium (OR\u00a0=\u00a00.999, 95% CI\u00a0=\u00a00.998, 1.000,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.229) and AS. The IVW (OR\u00a0=\u00a01.001, 95% CI\u00a0=\u00a01.000, 1.002,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.029) and WM<jats:sup>1<\/jats:sup>(OR\u00a0=\u00a01.001, 95% CI\u00a0=\u00a01.000, 1.002,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.011) results of zinc show that per standard deviation increment in zinc is a suggestive association with risks of AS, and MR\u2010Egger (OR\u00a0=\u00a01.004, 95% CI\u00a0=\u00a00.996, 1.013,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.265) and other supplementary methods indicate that zinc is not causally associated with AS. All MR\u2010Egger intercept parameters and MR Pleiotropy RESidual Sum and Outlier tests demonstrated the absence of horizontal pleiotropy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study does not provide convincing evidence to support a causal correlation between calcium, zinc, copper, and selenium with AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14390","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T06:11:13Z","timestamp":1658211073000},"page":"1129-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Common mineral nutrients in ankylosing spondylitis: A\u00a02\u2010sample Mendelian randomization study"],"prefix":"10.1111","volume":"25","author":[{"given":"Xiaoya","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-7687","authenticated-orcid":false,"given":"Shanshan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunity the First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-1025","authenticated-orcid":false,"given":"Faming","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406182"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0489-6"},{"key":"e_1_2_8_4_1","unstructured":"MorrisA L MohiuddinS S.Biochemistry nutrients [M]. statpearls. treasure island (FL); statpearls publishing copyright \u00a9 2022 statpearls publishing LLC.2022."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008937"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2020.100112"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.11.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.35.5.443"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.07.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784402"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060624"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.03.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1458804"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00103C"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115647"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03171-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4987"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34026-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.08.022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111391"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0325-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2019.07.007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102426"},{"issue":"18","key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"e2127","DOI":"10.1212\/WNL.0000000000006800","article-title":"Total intake of different minerals and the risk of multiple sclerosis [J]","volume":"92","author":"Cortese M","year":"2019","journal-title":"Neurology"},{"issue":"9","key":"e_1_2_8_27_1","first-page":"1192","article-title":"From genome\u2010wide association studies to mendelian randomization: novel opportunities for understanding cardiovascular disease causality, pathogenesis, prevention, and treatment [J]","volume":"114","author":"Benn M","year":"2018","journal-title":"Cardiovasc Res"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-007-0448-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003796"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt239"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu546"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy081"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-019-0051-2"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq151"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0255-x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy284"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0631-4"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8981"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy129"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00182"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.08.040"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2018.05.001"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T10:38:51Z","timestamp":1727606331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/1756-185X.14390"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14390","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"assertion":[{"value":"2022-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}