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Our objectives were to: (1) investigate the frequency, severity and gender difference of symptoms in patients with ankylosing spondylitis (AS); and (2) identify symptom clusters in AS patients. A cross\u2010sectional questionnaire\u2010based survey was conducted using the Patient Health Questionnaire Symptoms Group combined with self\u2010designed variables. Demographic and symptom variables between male and female patients in terms of C\u2010reactive protein (CRP) and <jats:italic>human leukocyte antigen<\/jats:italic> (<jats:italic>HLA<\/jats:italic>)\u2010<jats:italic>B27<\/jats:italic> status were analyzed with 2\u2010tailed independent <jats:italic>t<\/jats:italic> test for continuous variables and Chi\u2010square or Fisher's exact test for categorical variables. Symptom clusters were extracted and analyzed by principal component analysis. There were 122 AS patients included in the study. The most severe symptoms included severe back pain, extremity or joint pain, difficulty in breathing, constipation, intestine discomfort and diarrhea. Stomachache was more prevalent in male patients in which odds ratio was 4.60 (CI 1.59\u201012.97) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Patients with <jats:italic>HLA\u2010B27<\/jats:italic> negativity or a higher CRP value were more likely to have dry mouth. Four symptom clusters were classified, which explained 58.4% of the total variation. They were named as the gastrointestinal\u2010cardiac cluster, the fatigue\u2010sleep disturbance cluster, the headache\u2010chest pain cluster, and the mouth\u2010eye cluster. The symptoms appeared to cluster into 4 groups in AS patients, which should be noticed in clinical care.<\/jats:p>","DOI":"10.1111\/1756-185x.14391","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T06:18:08Z","timestamp":1659161888000},"page":"1137-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of symptom clusters in patients with ankylosing spondylitis"],"prefix":"10.1111","volume":"25","author":[{"given":"Wen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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