{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:19:51Z","timestamp":1769023191020,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection and the resulting coronavirus 2019 disease (COVID\u201019) have spread all around the world since 2019 and have affected millions of people. The development of COVID\u201019 vaccines helped to decelerate the spread of the virus. However, as in the case of vaccines against other infectious diseases, adverse events can also present with COVID\u201019 vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We report here a rare case of a 53\u2010year\u2010old man with knee\u2010joint synovitis, after the first dose of messenger RNA vaccine, with no fever and a negative COVID\u201019 reverse transcription polymerase chain reaction test. During a clinical examination the suspicion of pyogenic arthritis was excluded by blood tests and by a complex joint effusion examination, including a microbiological and cytological\u2010energy analysis of the synovial fluid. The treatment received by our patient consisted of 3 doses of dexamethasone administered intravenously over a period of 3\u2009days. All the symptoms improved after this therapy, and in the 3\u2010week follow\u2010up period we recorded full recovery with no consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Case reports on patients undergoing COVID\u201019 vaccination should be examined in order to detect rare and long\u2010term side\u2010effects. This is the first report to present the outcomes of an ultrastructural analysis of post\u2010vaccination synovitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14411","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T07:54:29Z","timestamp":1659686069000},"page":"1324-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Reactive synovitis of the knee joint after <scp>COVID<\/scp>\u201019 vaccination: The first ultrastructural analysis of synovial fluid"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9211-2226","authenticated-orcid":false,"given":"Eliska","family":"Vanaskova","sequence":"first","affiliation":[{"name":"Department of Orthopaedics University J. E. Purkinje and Masaryk Hospital  Usti nad Labem Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-6827","authenticated-orcid":false,"given":"Petr","family":"Kelbich","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Laboratory Diagnostics University J. E. Purkinje and Masaryk Hospital  Usti nad Labem Czech Republic"},{"name":"Department of Clinical Immunology and Allergology, Faculty of Medicine University Hospital in Hradec Kralove, Charles University in Prague  Hradec Kralove Czech Republic"},{"name":"Laboratory for Cerebrospinal Fluid, Neuroimmunology, Pathology and Special Diagnostics Topelex  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-0038","authenticated-orcid":false,"given":"Tomas","family":"Novotny","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University J. E. Purkinje and Masaryk Hospital  Usti nad Labem Czech Republic"},{"name":"Department of Histology and Embryology, Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1920274"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249775"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2020.105086"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12020160"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12030994"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23526"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0346"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108256"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14202"},{"key":"e_1_2_10_12_1","first-page":"6","article-title":"Principles of the cytological\u2010energy analysis of the extravascular body fluids","volume":"3","author":"Kelbich P","year":"2017","journal-title":"Biochem Mol Biol J"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001350"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217914"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.33590\/emj\/21-00261"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:28:39Z","timestamp":1692613719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/1756-185X.14411"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14411","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}