{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:46:17Z","timestamp":1774615577479,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Newly developed Doppler techniques enable the sampling of slow vascular flows and the extrapolation of spectral parameters in distal arterioles. The aim of this study was to investigate the role of spectral analysis performed by means of ultra\u2010high frequency ultrasound (US) in the evaluation of the peripheral vascular bed of systemic sclerosis (SSc) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both hands of 33 patients affected by diffuse cutaneous SSc and 34 volunteers were evaluated with a US machine equipped with 33\u20109\u00a0MHz and 18\u20105\u00a0MHz transducers. Proximal resistive index and the peak systolic velocity (pRI and pPSV, respectively), were calculated at the level of the second interdigital artery. The distal resistive index (dRI) was calculated at the level of a nailfold arteriole of the third finger. All SSc patients had been previously divided into 4 subgroups according to their nailfold videocapillaroscopic (NVC) patterns following accepted criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SSc patients showed a significantly slower systolic velocity at the level of the second interdigital artery (pPSV [SD]\u00a0=\u00a08.38 [3]\u00a0cm\/s vs pPSV [SD]\u00a0=\u00a011.14 [4.5]\u00a0cm\/s; <jats:italic>P<\/jats:italic>\u00a0=\u2009.005) and a higher dRI (dRI [SD]\u00a0=\u00a00.65 (0.14) vs dRI [SD]\u00a0=\u00a00.57 [0.11); <jats:italic>P<\/jats:italic>\u00a0=\u2009.0115). No differences were found between the pRI values measured in the SSc patients and those of the controls (pRI [SD]\u00a0=\u00a00.76 [0.11] vs pRI [SD]\u00a0=\u00a00.73 [0.12]; <jats:italic>P<\/jats:italic>\u00a0=\u2009.359]. The subgroup analysis did not show any significant difference when pPSV, pRI and dRI were compared among NVC morphological patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010resolution Doppler analysis of digital distal arterioles may disclose subtle abnormalities in the downstream microvasculature of SSc patients that could be missed when the examination is performed at a more proximal level and\/or using lower Doppler frequencies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14422","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T05:22:30Z","timestamp":1660368150000},"page":"1288-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High\u2010resolution Doppler ultrasound in systemic sclerosis: Analysis of digital arteries and nailfold microvasculature using 18\u20105\u2009MHz and 33\u20109\u2009MHz probes"],"prefix":"10.1111","volume":"25","author":[{"given":"Riccardo","family":"Picasso","sequence":"first","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Bica","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Specialties (DIMI) University of Genoa  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-3672","authenticated-orcid":false,"given":"Federico","family":"Pistoia","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Department of Experimental Medicine (DIMES) University of Genoa  Genoa 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Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Specialties (DIMI) University of Genoa  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Paolino","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Specialties (DIMI) University of Genoa  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Sulli","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Specialties (DIMI) University of Genoa  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Gotelli","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Rheumatology and Academic Division of 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