{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:29:26Z","timestamp":1747182566087,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a rare case of long\u2010standing Hailey\u2010Hailey disease in a Caucasian Portuguese 69\u2010year\u2010old woman, recently diagnosed with rheumatoid arthritis. The patient's skin lesions remained active and exudative despite topical and oral treatments with corticosteroids, tetracyclines, antifungals, and oral treatment with azathioprine. After introduction of methotrexate for rheumatoid arthritis treatment, the skin lesions regressed, with significant impact on the patient's quality of life. This case report supports the clinical evidence of methotrexate's potential role in Hailey\u2010Hailey disease treatment.<\/jats:p>","DOI":"10.1111\/1756-185x.14456","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T04:56:57Z","timestamp":1665464217000},"page":"157-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rheumatoid arthritis and <scp>Hailey\u2010Hailey<\/scp> disease treated with methotrexate"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-5318","authenticated-orcid":false,"given":"Beatriz","family":"Mestre","sequence":"first","affiliation":[{"name":"Unidade de Sa\u00fade Familiar Almonda ACeS M\u00e9dio Tejo  Torres Novas Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garcia","sequence":"additional","affiliation":[{"name":"Rheumatology Department Centro Hospitalar do M\u00e9dio Tejo  Torres Novas Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-8492","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Madruga Dias","sequence":"additional","affiliation":[{"name":"Rheumatology Department Centro Hospitalar do M\u00e9dio Tejo  Torres Novas Portugal"},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas Nova Medical School  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00477-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14198"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"issue":"10","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/ddg.14619","article-title":"Hailey\u2010Hailey disease: update 2021","volume":"19","author":"Rogner DF","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14225"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03360.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2012.1098"},{"key":"e_1_2_5_10_1","unstructured":"MorrellD.Hailey\u2010Hailey disease (benign familial pemphigus). In:HandJL ed.UpToDate;2022.https:\/\/www.uptodate.com\/contents\/hailey\u2010hailey\u2010disease\u2010benign\u2010familial\u2010pemphigus\/contributorsAccessed on August 2022."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44514"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410025462"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2011.00839.x"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14456","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T16:35:27Z","timestamp":1692462927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,10]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/1756-185X.14456"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14456","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2022,10,10]]},"assertion":[{"value":"2022-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}