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Thus, it is important to explore the role of gene regulation related with ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Constructed a RA\u2010ILD\u2010related long chain noncoding RNA \u2013 messenger RNA (lncRNA\u2010mRNA) network (ILD\u2010LMN), based on ILD\u2010 and RA\u2010related genes. We analyzed the topological properties of the resulting network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The results for network modularization and functional analysis showed that ILD\u2010LMN performed basic and specific functions in ILD pathology. Furthermore, differential expression and correlation analysis of hub nodes revealed highly correlated competitive endogenous RNA regulatory relationships with important roles in pathological regulation. Following this, statistical analysis of disease\u2010related single nucleotide polymorphisms (SNPs) in hub lncRNAs revealed that some of transcription factor\u2010related SNPs were significantly associated with the expression of lncRNA. In fact, these SNPs exhibited significant differential expression in disease and normal samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that ILD\u2010LMN has important implications in the study of disease. Altogether, the study of RA\u2010 and ILD\u2010related lncRNA and genes on the basis of biological network would assist in providing better treatment opportunities for ILD patients. Additionally, it would promote further research on treatment of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14466","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T03:59:15Z","timestamp":1666238355000},"page":"132-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Construction and comprehensive analysis of the biological network related to rheumatoid arthritis\u2010related interstitial lung disease"],"prefix":"10.1111","volume":"26","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Rheumatology Liaocheng People's Hospital Liaocheng China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Dongying People's Hospital Dongying 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