{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:11:04Z","timestamp":1768014664976,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients with polyarteritis nodosa (PAN) complicated by digital gangrene have poor outcomes and related research information is limited. Our aim is to identify the associated risk and prognostic factors in PAN patients with digital gangrene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We conducted a retrospective study of 148 PAN patients admitted to Peking Union Medical College Hospital from Octorber 2001 to December 2018. Forty\u2010seven (31.8%) PAN patients had digital gangrene. The average age was 40.4\u2009\u00b1\u200917.9\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of digital gangrene was correlated with current smoking (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008, odds ratio [OR] 2.99, 95% CI, 1.33\u20136.73), eosinophil elevation (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003, OR 4.21, 95% CI, 1.62\u201310.91) and elevated leukocytes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, OR 4.26, 95% CI, 1.86\u20139.78). Thirty\u2010two (68.1%) gangrene patients received methylprednisolone pulse therapy and all of these patients were treated with cyclophosphamide. Nine patients suffered irreversible organ injury and 2 died. Survival analysis showed higher serum C\u2010reactive protein (CRP) was associated with poor prognosis in patients with gangrene (log\u2010rank <jats:italic>P<\/jats:italic>\u00a0=\u00a00.042 and generalized Wilcoxon <jats:italic>P<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PAN patients with current smoking and eosinophil elevation were more prone to digital gangrene and a high serum CRP level predicted poor outcomes. The CRP level should be efficiently controlled to ensure a good prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14467","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T03:54:48Z","timestamp":1666238088000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identifying risk and prognostic factors in polyarteritis nodosa patients with digital gangrene"],"prefix":"10.1111","volume":"26","author":[{"given":"Lin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"},{"name":"The Department of Rheumatology 2nd Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-4588","authenticated-orcid":false,"given":"Xiaodan","family":"Kong","sequence":"additional","affiliation":[{"name":"The Department of Rheumatology 2nd Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-3495","authenticated-orcid":false,"given":"Jiaxin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangzhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-3043","authenticated-orcid":false,"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-7952","authenticated-orcid":false,"given":"Xinping","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; 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