{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:43:44Z","timestamp":1785293024899,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000544","name":"British Association for Psychopharmacology","doi-asserted-by":"publisher","award":["34213"],"award-info":[{"award-number":["34213"]}],"id":[{"id":"10.13039\/501100000544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to investigate the possible relationship between the serum S100A12 and Toll\u2010like receptor 4 (TLR4) levels, and the activity of familial Mediterranean fever (FMF) and juvenile idiopathic arthritis (JIA) in accordance with the routine biochemical parameters. Furthermore, the effectiveness of these 2 biomarkers in distinguishing FMF from JIA has been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010nine children with FMF, 68 children with JIA, and 35 healthy children were included in this study. S100A12 and TLR4 levels were measured by the sandwich enzyme\u2010linked immunosorbent assay technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the FMF patient group, serum S100A12 level was found to be significantly higher than in both the JIA and control groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.000 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000, respectively). Although S100A12 levels were higher in the attack period compared to the attack\u2010free period, this increase was not statistically significant (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). TLR4 levels were statistically significantly higher in the attack period compared to the attack\u2010free period in children with FMF (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Although there was no relationship between S100A12 levels and disease activity, there is a clear correlation between S100A12 and the Auto\u2010Inflammatory Disease Activity Index in attack\u2010free FMF patients (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.612 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum S100A12 levels were not found to be a potentially valuable biomarker for assessing disease activity in either FMF or JIA. However, TLR4 levels were found to be a valuable biomarker for assessing disease activity in children with FMF. Further research which includes serial monitoring of S100A12 and TLR4 levels in a large cohort will provide detailed information about accuracy of these 2 potential biomarkers in both patients group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14475","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:14:45Z","timestamp":1666916085000},"page":"250-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of <scp>S100A12<\/scp> and <scp>Toll\u2010like receptor 4<\/scp> in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8893-2926","authenticated-orcid":false,"given":"Seyma","family":"Dumur","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine Istanbul University\u2010Cerrahpasa  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