{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:49:26Z","timestamp":1779356966991,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017332","name":"Rafsanjan University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.RUMS.REC.1400.169"],"award-info":[{"award-number":["IR.RUMS.REC.1400.169"]}],"id":[{"id":"10.13039\/100017332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several investigations have disclosed the involvement of the interleukin (IL)\u201023\/IL\u201017 pathway in rheumatoid arthritis (RA) pathogenesis. Here we investigated the association of single nucleotide polymorphisms (SNPs) in the <jats:italic>IL23 receptor<\/jats:italic> (<jats:italic>IL23R<\/jats:italic>) gene with RA risk. In addition, the role of these SNPs with the inflammatory state of the patients were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2010control study, 200 RA cases and 200 healthy subjects were recruited. Using allelic discrimination real\u2010time polymerase chain reaction, both <jats:italic>IL23R<\/jats:italic> rs10489629 and rs1004819 SNPs were genotyped. The messenger RNA (mRNA) expression levels of IL\u201023R, IL\u201023, and IL\u201017A were determined in peripheral blood mononuclear cells (PBMCs). The serum levels of IL\u201023 and IL\u201017A were also determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The A allele (odds ratio [OR]\u00a0=\u00a01.52, 95% CI: 1.15\u20102.01; <jats:italic>P<\/jats:italic>\u00a0=\u2009.0030), AA genotype (OR\u00a0=\u00a02.41, 95% CI: 1.33\u20104.35; <jats:italic>P<\/jats:italic>\u00a0=\u2009.0035), and AG genotype (OR\u00a0=\u00a02.55, 95% CI: 1.56\u20104.16, <jats:italic>P<\/jats:italic>\u00a0=\u2009.0002) of rs1004819 SNP was significantly associated with increased RA risk. The mRNA expression of IL\u201017A (fold change\u00a0=\u00a02.55, <jats:italic>P<\/jats:italic>\u00a0=\u2009.00027), IL\u201023 (fold change\u00a0=\u00a01.62, <jats:italic>P<\/jats:italic>\u00a0=\u2009.0081), and IL\u201023R (fold change\u00a0=\u00a01.59, <jats:italic>P<\/jats:italic>\u00a0=\u2009.0077) was significantly upregulated in the PBMCs from RA patients compared to that of healthy controls. Serum levels of IL\u201017A (<jats:italic>P<\/jats:italic>\u00a0=\u2009.00019) and IL\u201023 (<jats:italic>P<\/jats:italic>\u00a0=\u2009.00055) was significantly higher in the RA patients compared to the controls. No significant association was detected between patient data and SNPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IL\u201023\/IL\u201027 pathway plays a role in RA pathogenesis, but <jats:italic>IL23R<\/jats:italic> gene rs1004819 SNP might not be regulating this pathway in RA disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14479","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:34:53Z","timestamp":1666917293000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interleukin 23 receptor gene polymorphisms and their role in the inflammatory status of rheumatoid arthritis patients in an Iranian population"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8149-8549","authenticated-orcid":false,"given":"Mitra","family":"Abbasifard","sequence":"first","affiliation":[{"name":"Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences  Rafsanjan Iran"},{"name":"Department of Internal Medicine, Ali\u2010Ibn Abi\u2010Talib Hospital, School of Medicine Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences  Rafsanjan Iran"},{"name":"Department of Clinical Biochemistry, School of Medicine Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Abade","sequence":"additional","affiliation":[{"name":"Student Research Committee Rafsanjan University of Medical Sciences  Rafsanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-1470","authenticated-orcid":false,"given":"Zahra","family":"Bagheri\u2010Hosseinabadi","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences  Rafsanjan Iran"},{"name":"Department of Clinical Biochemistry, School of Medicine Rafsanjan University of Medical Sciences  Rafsanjan 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