{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:20:42Z","timestamp":1793283642207,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyze the clinical patterns of new\u2010onset inflammatory arthritis after COVID\u201019 vaccination among patients without pre\u2010existing rheumatic or autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Case reports and series of new\u2010onset inflammatory arthritis after COVID\u201019 vaccination were collected before April 2022. Clinical characteristics including diagnosis, age, gender, vaccine types, time interval between events, joint involvement (poly\u2010 or oligo\u2212\/monoarthritis), and laboratory data reflecting inflammatory status were sorted and\n                      <jats:italic>P<\/jats:italic>\n                      values between these parameters are calculated with independent sample Student's\n                      <jats:italic>t<\/jats:italic>\n                      test or 2\u2009\u00d7\u20092 Fisher's exact test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 39 cases with new\u2010onset post\u2010vaccination arthritis including 25 females and 13 males (1 unknown), the most common diagnosis is adult\u2010onset Still's disease (AoSD, 10 cases), and the most common vaccine types are BNT162b2 (16 cases) and AZD\u20101222 (or ChAdOx1\u2010nCoV19, 15 cases). Sub\u2010analysis reveals that post\u2010vaccination polyarthritis is more common among females (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.016, by 2\u2009\u00d7\u20092 Fisher's exact test, compared with male patients) and older patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.006, by Student's\n                      <jats:italic>t<\/jats:italic>\n                      test). The C\u2010reactive protein level is significantly higher in cases with post\u2010vaccination inflammatory polyarthritis than oligoarthritis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.029), as well as in cases with AoSD than other causes of post\u2010vaccination arthritis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004). However, serum level of erythrocyte sedimentation rate in patients with post\u2010vaccination AoSD are independent of other clinical variables in the analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>New\u2010onset post\u2010vaccination polyarthritis are more common in females and older patients. Although COVID\u201019 vaccines may lead to inflammatory arthritis, the benefits of vaccination substantially outweigh the potential risks of such serious adverse effects due to their rarity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14482","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T01:04:43Z","timestamp":1668301483000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<scp>New\u2010onset<\/scp>\n                    inflammatory arthritis after\n                    <scp>COVID<\/scp>\n                    \u201019 vaccination: A systematic review"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-0576","authenticated-orcid":false,"given":"Cheng\u2010Che","family":"Chen","sequence":"first","affiliation":[{"name":"College of Chinese Medicine China Medical University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-2335","authenticated-orcid":false,"given":"Chung\u2010Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy Immunology and Rheumatology, Kaohsiung Medical University Chung\u2010Ho Memorial Hospital  Kaohsiung Taiwan"},{"name":"Department of Traditional Chinese Medicine Kaohsiung Medical University Chung\u2010Ho Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"COVID\u201019 Map Johns Hopkins Coronavirus Resource Center 2022 Accessed 1st April 2022.https:\/\/coronavirus.jhu.edu\/map.html"},{"key":"e_1_2_8_3_1","unstructured":"COVID\u201019 Vaccines United States Food and Drug Administration (U.S. FDA) 2022 Accessed 1st Aprilhttps:\/\/www.fda.gov\/emergency\u2010preparedness\u2010and\u2010response\/coronavirus\u2010disease\u20102019\u2010covid\u201019\/covid\u201019\u2010vaccines"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13443"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221490"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41928"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221587"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-08"},{"key":"e_1_2_8_9_1","first-page":"2615","volume-title":"Harrison's Principles of Internal Medicine","author":"Cush JJ","year":"2018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00219-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108878"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e344"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"3","article-title":"Hyper\u2010inflammation after COVID\u201019 mARN vaccination: at the crossroads of multisystem inflammatory disease and adult\u2010onset Still's disease. 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