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Laboratory investigations revealed elevated serum erythrocyte sedimentation rate and C\u2010reactive protein. Synovial aspiration yielded level 3 crystal\u2010free, aseptic and inflammatory effusion. She tested positive for the human leukocyte antigen\u2010B27 and was diagnosed with peripheral SpA. She received daily celecoxib (400\u2009mg), methylprednisolone (8\u00a0mg), and sulfasalazine (2\u00a0g), but the effect was limited. Nonetheless, her symptoms improved significantly with weekly subcutaneous etanercept administration (50\u2009mg). Four weeks later, her arthritis was completely resolved. To our knowledge, this is the first case report of newly diagnosed seronegative peripheral SpA in an autoimmunity\u2010disease\u2010free individual following messenger RNA BNT coronavirus disease 2019 vaccination.<\/jats:p>","DOI":"10.1111\/1756-185x.14512","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T22:26:59Z","timestamp":1670538419000},"page":"774-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prolonged peripheral seronegative spondyloarthritis following <scp>BioNTech<\/scp> coronavirus disease 2019 vaccination: A case report"],"prefix":"10.1111","volume":"26","author":[{"given":"Shu\u2010Yi","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Medicine Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Occupational Medicine Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-646X","authenticated-orcid":false,"given":"Chung\u2010Yuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050435"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-01018-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13443"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06149-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1920274"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108256"},{"key":"e_1_2_9_9_1","first-page":"100","article-title":"Inactivated COVID\u201019 vaccine can induce reactive polyarthritis IN older patients: report of two cases","volume":"319","author":"T\u00fcrk SM","year":"2021","journal-title":"Georgian Med News"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14202"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.04.047"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.03.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9080815"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0451-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108480"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14512","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:50:21Z","timestamp":1754995821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/1756-185X.14512"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14512","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,8]]},"assertion":[{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}