{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:36:34Z","timestamp":1791959794472,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cogan's syndrome (CS) is a rare autoimmune disease in which approximately 10%\u201313% of people with the condition develop neurological symptoms. While glucocorticoids are the standard of care for patients with CS, disease\u2010modifying anti\u2010rheumatic drugs (DMARDs) and biologics agents are more widely used to treat the systemic and vestibular auditory manifestations of CS. Herein, we report a rare case of CS with central nervous system damage who failed to respond to systemic use of glucocorticoids and DMARDs. However, his symptoms were successfully improved by intrathecal injection of methotrexate (MTX) and dexamethasone. To our knowledge, the use of intrathecal injections of MTX and dexamethasone to treat CS has not been reported in any literature. Therefore, the present case may provide a new idea for clinicians to treat central nervous system symptoms in patients with CS.<\/jats:p>","DOI":"10.1111\/1756-185x.14518","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T07:17:02Z","timestamp":1672903022000},"page":"786-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intrathecal injection of methotrexate combined with dexamethasone for Cogan's syndrome with neurological involvement: A case report and literature review"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-0978","authenticated-orcid":false,"given":"Jiarui","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Rheumatology and Immunology Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4252-6559","authenticated-orcid":false,"given":"Hongjia","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Rheumatology and Immunology Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Rheumatology and Immunology Chinese Academy of Sciences Sichuan Translational Medicine 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"},{"name":"Department of Rheumatology and Immunology Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital  Chengdu 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