{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:25:19Z","timestamp":1773087919657,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Relatively recently, the concept that immunoglobulin G4 (IgG4)\u2010related disease is a distinct chronic inflammatory disorder rather than a subset of Sj\u00f6gren's syndrome has been accepted. IgG4\u2010related disease (IgG4\u2010RD) is a fibro\u2010inflammatory systemic immune\u2010mediated condition that can affect the pancreas, salivary glands, and lymph nodes. Almost every organ may be impacted synchronously or metachronously by this illness, which causes the development of sclerotic masses of varying sizes. Numerous other rheumatic diseases can present with characteristics of IgG4\u2010RD, making it difficult to distinguish between them. However, cases of IgG4\u2010RD involving the bilateral orbits, and pancreas with biological abnormalities are rare. We present a case of an 18\u2010year\u2010old female with vitiligo since the age of 3\u2009years who presented with acute pancreatitis and acalculous cholecystitis, bilateral orbital masses, palpebral edema, and eosinophilia. The patient was diagnosed with IgG4\u2010RD in keeping with clinical presentation and the elevated serum IgG4 level and after elimination of other differential diagnoses. The patient's symptoms gradually relieved after glucocorticoid therapy. This case presents an uncommon combination of clinical features infrequently reported in the literature. Multi\u2010organ IgG4\u2010RD is a multisystemic mass, commonly creating diagnostic challenges for clinicians. Furthermore, and more importantly, it highlights the need to keep a differential of IgG4\u2010RD in mind, to aid in the early and correct treatment of the disease.<\/jats:p>","DOI":"10.1111\/1756-185x.14521","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T17:56:41Z","timestamp":1669744601000},"page":"531-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Orbital inflammatory pseudotumor revealing multi\u2010organ <scp>immunoglobulin G4<\/scp>\u2010related disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-3418","authenticated-orcid":false,"given":"Raida","family":"Ben Salah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Sfax  Sfax 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