{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:34:52Z","timestamp":1789220092044,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017534","name":"Project 333 of Jiangsu Province","doi-asserted-by":"publisher","award":["BRA2020175"],"award-info":[{"award-number":["BRA2020175"]}],"id":[{"id":"10.13039\/501100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016022","name":"Data Center of Management Science, National Natural Science Foundation of China - Peking University","doi-asserted-by":"publisher","award":["82071821"],"award-info":[{"award-number":["82071821"]}],"id":[{"id":"10.13039\/501100016022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20201222"],"award-info":[{"award-number":["BK20201222"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the utility of magnetic resonance imaging (MRI) and magnetic resonance sialography (MRS) for diagnosis of primary Sj\u00f6gren syndrome (pSS) singly or integrated with 2016 American College of Rheumatology (ACR)\/European League Against Rheumatic Diseases (EULAR) classification criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The diagnostic efficiencies of MRI, MRS, and labial salivary gland biopsy (LSGB) were evaluated. The prediction model was established by multivariate analysis. Finally, performance of the ACR\/EULAR criteria was evaluated after addition of MRI\u2009+\u2009MRS or replacement of original items by MRI\u2009+\u2009MRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combined use of LSGB\u2009+\u2009MRI\u2009+\u2009MRS provided the greatest diagnostic value. MRI and MRS grade had positive correlations with disease duration and pathological grade of the labial gland (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). MRI and MRS grade had positive correlations with xerostomia severity and negative correlations with unstimulated salivary flow rate (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The consistency of MRI grade and MRS grade in the diagnosis of parotid gland lesions was poor (\u03ba\u00a0=\u00a00.253, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The diagnostic efficiency of our prediction model (AUC 0.906) was similar to that of criteria from the ACR\/EULAR (AUC 0.930). Adding MRI\u2009+\u2009MRS to the ACR\/EULAR criteria improved the sensitivity (92.3% vs 90.8%), whereas the specificity remained the same (88.9% vs 89.1%). Replacing LSGB by MRI\u2009+\u2009MRS in the ACR\/EULAR criteria decreased both sensitivity and specificity (88.1% vs 90.8% and 86.4% vs 89.1%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined application of MRI and MRS has ideal clinical application value in the diagnosis of early\u2010stage pSS. Validity of the ACR\/EULAR criteria remains high after incorporation of MRI\u2009+\u2009MRS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14528","type":"journal-article","created":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T19:14:35Z","timestamp":1670786075000},"page":"454-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Value of magnetic resonance imaging and sialography of the parotid gland for diagnosis of primary Sj\u00f6gren syndrome"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-0182","authenticated-orcid":false,"given":"Yujun","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University Yangzhou University  Yangzhou 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