{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:58:09Z","timestamp":1789268289934,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) has the potential to affect virtually every organ; however, gastrointestinal system manifestations are relatively rare compared to other autoimmune diseases such as systemic sclerosis and inflammatory bowel disease. A 29\u2010year\u2010old female patient attended to the emergency room with abdominal distention, acute onset abdominal pain and constipation. She had watery chronic diarrhea (4\u20105 times\/d) and weight loss (6\u2009kg, 12%) for 4 months. While there was increased intestinal wall thickness, air\u2010liquid levels were shown on abdomen computed tomography scan. The patient underwent abdominal surgery due to diagnosis of ileus. Ileocecal resection was performed and pathologic evaluation revealed intestinal lymphangiectasia. Autoimmune serology was performed with the following resulats: anti\u2010nuclear antibody 1\/3200 with homogenous pattern, anti\u2010DNA antibody and anti\u2010Sm\/ribonucleoprotein antibodies were positive in addition to low complement levels (C3: 0.28 [0.9\u20101.8\u2009g\/L], C4: 0.06 [0.1\u20100.4\u2009g\/L]) indicating diagnosis of SLE. Development of intestinal involvement in SLE (lupus enteritis) is mainly grouped into 3 headings such as mesenteric vasculitis, pseudo\u2010obstruction, and protein\u2010losing enteropathy. Although the pathogenesis of intestinal lymphangiectasia remains unknown, it has been reported that immune complex\u2010mediated visceral vasculitis may result in bowel wall and mucosal edema. To our knowledge this is the first case report accompanying hyperinflammatory response in addition to intestinal lymphangiectasia in SLE. On the other hand, clinicians should be alert for other reasons for hyperinflammatory syndromes rather than COVID\u201019, even during the pandemic.<\/jats:p>","DOI":"10.1111\/1756-185x.14541","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T09:46:45Z","timestamp":1671788805000},"page":"591-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A case of systemic lupus erythematosus presenting with intestinal lymphangiectasia\u2010associated protein\u2010losing enteropathy accompanying hyperinflammation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-3837","authenticated-orcid":false,"given":"Murat","family":"Bekta\u015f","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Aksaray Training and Research Hospital  Aksaray 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