{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T20:03:56Z","timestamp":1772395436707,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical trial evidence demonstrates the efficacy of tofacitinib in ankylosing spondylitis and psoriatic arthritis (PsA). Real\u2010world data from spondyloarthritis (SpA) patients are scarce; there are few reports of its effectiveness and safety from low\u2010 to middle\u2010income countries like India, despite its widespread usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of clinical and laboratory records of 100 patients with SpA prescribed generic tofacitinib from a single center in Mumbai, India. Disease activity was measured using the Ankylosing Spondylitis Disease Activity Score C\u2010Reactive Protein (ASDAS\u2010CRP) in all patients, along with disease\u2010specific outcome measures in the subgroups. We used paired <jats:italic>t<\/jats:italic> test for response to tofacitinib. We compared \u0394 ASDAS\u2010CRP in patients with active peripheral arthritis and in patients without. We defined clinical tofacitinib failure as the physician's decision to change or add a disease\u2010modifying antirheumatic drug (DMARD), and performed logistic regression to identify factors associated with tofacitinib failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 100 patients (71 male, median age 42.5\u2009years), 57 had axial SpA, 10 had peripheral SpA, 4 had inflammatory bowel disease\u2010SpA and 29 had PsA. One\u2010third had received biologic DMARDs previously. Patients received tofacitinib for a median of 192\u2009days. There was a significant improvement in ASDAS\u2010CRP in all types of SpA. Patients with active peripheral arthritis had a significantly greater fall in ASDAS\u2010CRP. There were no serious adverse events, 19 patients had mild COVID\u201019; no patient had tuberculosis. Ten patients had tofacitinib failure; no baseline parameter could predict failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In the real\u2010world setting, generic tofacitinib showed good effectiveness and tolerable safety profile in Indian patients with SpA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14570","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T05:33:58Z","timestamp":1674279238000},"page":"487-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness and safety of generic tofacitinib in spondyloarthritis: A real\u2010world retrospective analysis from India"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-9956","authenticated-orcid":false,"given":"Sanat","family":"Phatak","sequence":"first","affiliation":[{"name":"K.E.M. Hospital Research Centre  Pune India"},{"name":"B.J. Medical College and Sassoon General Hospital  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Khenat","sequence":"additional","affiliation":[{"name":"B.J. Medical College and Sassoon General Hospital  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansi","family":"Malandkar","sequence":"additional","affiliation":[{"name":"Rheumatic Disease Clinic  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Amin","sequence":"additional","affiliation":[{"name":"Rheumatic Disease Clinic  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.suppl_3.iii8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150640"},{"key":"e_1_2_9_5_1","first-page":"318","article-title":"The mechanism of action of tofacitinib \u2010 an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis","volume":"34","author":"Hodge JA","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615975"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219601"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606910"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01255-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4111-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.13.129775"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508207221"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210322"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06205-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.201681"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes059"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-048647"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-020-00209-4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001595"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207319"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.08.22273582"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101643"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14570","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T19:41:51Z","timestamp":1692301311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/1756-185X.14570"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14570","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}