{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:41:46Z","timestamp":1793788906828,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether complications of pulmonary hypertension (PH) can be predicted by noninvasive screening tests in systemic sclerosis (SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven of 113 SSc patients underwent right heart catheterization (RHC) during 2011\u20132014. Clinical data, hemodynamic features, echocardiography, and pulmonary function tests had been followed up from the first RHC until 5\u2009years later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the first RHC, out of 44 patients, 8 were diagnosed with pre\u2010capillary PH (mean pulmonary arterial pressure [mPAP]\u2009&gt;\u200920\u2009mm\u2009Hg), and 36 patients were defined as no\u2010PH (mPAP\u2009\u2264\u200920\u2009mm\u2009Hg). Three patients with &gt;15\u2009mm\u2009Hg of pulmonary artery wedge pressure were excluded. Receiver operating characteristic analyses for pre\u2010capillary PH using estimated systolic PAP (esPAP) revealed an area under the curve (AUC) of 0.736, with a sensitivity and specificity of 62.5% and 86.1%, respectively, at a cutoff level of 35.0\u2009mm\u2009Hg. The predicted percentage diffusing lung capacity for carbon monoxide (DLCO%) revealed an AUC of 0.840, with a sensitivity and specificity of 85.7% and 80.0%, respectively, at a cutoff level of 70.0%. Six pre\u2010capillary PH patients, including one who died from PH 14\u2009months after the first RHC, indicated exacerbations of mPAP or esPAP within 5\u2009years. When esPAP\u2009&lt;\u200935.0\u2009mm\u2009Hg and DLCO%\u2009&gt;\u200970% were met as the cutoff, none had been newly diagnosed with PH over 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The conventional screening tests may be useful for detecting pre\u2010capillary PH with SSc, and both esPAP\u2009&lt;\u200935.0\u2009mm\u2009Hg and DLCO%\u2009&gt;\u200970% indicated a lower risk of developing PH for at least 5\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14576","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T03:45:02Z","timestamp":1675482302000},"page":"493-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combination of echocardiography and pulmonary function tests could predict no complication of pulmonary hypertension during 5\u2009years in patients with systemic sclerosis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-5116","authenticated-orcid":false,"given":"Katsuhiko","family":"Yoneda","sequence":"first","affiliation":[{"name":"The Center for Rheumatic Disease Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-0563","authenticated-orcid":false,"given":"Soshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"The Center for Rheumatic Disease Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shinko Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Iwahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shinko Hospital  Kobe 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