{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:18:18Z","timestamp":1759483098531,"version":"3.43.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The nature of neurovascular involvement in cases of familial Mediterranean fever (FMF) has not been adequately clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Patients<\/jats:title><jats:p>Clinical features, infarct topography, vascular status, and stroke etiology were prospectively determined in 35 acute neurovascular events that occurred in 23 FMF patients. Clinicoradiological features were compared with an age\u2010 and gender\u2010matched control group of 115 acute stroke patients. Characteristics of additional FMF and acute stroke cases (6 episodes in 6 patients) identified from a systematic literature review (PROSPERO registration no: CRD420212264820) were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 27 acute ischemic stroke episodes in 19 patients, 7 transient ischemic attack episodes in 3 patients, and 1 patient with a single episode of parietal hematoma in our cohort. Twenty (74%) ischemic stroke episodes in 12 patients were cryptogenic. Ten of these 12 cases had a previous FMF diagnosis and were taking colchicine. There was no significant difference in the FMF group in terms of the presence of vascular risk factors and angiography\u2010documented disease in comparison to controls. Cerebral distal artery involvement was significantly prevalent in FMF (78% vs 45%, <jats:italic>P<\/jats:italic>\u00a0=\u2009.002). Especially, midbrain central deep perforating territory involvement was higher (30% vs 1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). The long\u2010term prognosis (median 8.5\u2009years) under antiplatelet agents and colchicine is favorable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The acute stroke phenotype in FMF cases is herein described for the first time. Several clinicoradiological features such as thrombotic lacunar infarcts located in the central mesencephalon seem so typical that we recommend searching for FMF mutations in geographic regions where FMF is common.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14588","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T05:41:00Z","timestamp":1675662060000},"page":"657-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute stroke in familial Mediterranean fever: An analysis of 23 new cases and systematic review of the literature"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-1431","authenticated-orcid":false,"given":"Mehmet Akif","family":"Topcuoglu","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-2143","authenticated-orcid":false,"given":"Cansu","family":"Ayvacioglu\u2010Cagan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-4139","authenticated-orcid":false,"given":"Ethem Murat","family":"Arsava","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-0094","authenticated-orcid":false,"given":"P\u0131nar","family":"Acar\u2010Ozen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-2109","authenticated-orcid":false,"given":"Umut","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-9336","authenticated-orcid":false,"given":"Rahsan","family":"Gocmen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-5244","authenticated-orcid":false,"given":"Tayfun Hilmi","family":"Akbaba","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-8796","authenticated-orcid":false,"given":"Banu","family":"Balc\u0131\u2010Peynircio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-4483","authenticated-orcid":false,"given":"Meryem Asl\u0131","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Hospital Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.01.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez410"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181d5dca7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050134"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.02.017"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"5","article-title":"Familial Mediterranean fever; diagnosis, treatment, and complications","volume":"4","author":"Bashardoust B","year":"2015","journal-title":"J Nephropharmacol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20617"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179547617749208"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.29011\/IJCDS-107.100007"},{"issue":"3","key":"e_1_2_6_11_1","first-page":"93","article-title":"Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis","volume":"31","author":"Luger S","year":"2013","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"e_1_2_6_12_1","first-page":"246","article-title":"Brain stem infarction in a young patient associated with probable familial Mediterranean fever: a case report","volume":"27","author":"Altun\u0131\u015f\u0131k E","year":"2021","journal-title":"T\u00fcrk Beyin Damar Hast Derg"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.773"},{"key":"e_1_2_6_14_1","first-page":"21.029","article-title":"Conus medullaris infarction in a patient with familial Mediterranean fever: a case report","volume":"21","author":"Robinow Z","year":"2021","journal-title":"Perm J"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593374"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13473"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0705416"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3532-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04601-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04991-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu231"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.013"},{"issue":"1","key":"e_1_2_6_23_1","first-page":"9","article-title":"Prevalence of ischemic heart disease in patients with familial Mediterranean fever","volume":"3","author":"Langevitz P","year":"2001","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00763"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2001.19958"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0485-x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12581"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309103057"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.5455\/apr.061820130506"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2005.1.1.31"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050383"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T10:50:40Z","timestamp":1754995840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/1756-185X.14588"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14588","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"type":"print","value":"1756-1841"},{"type":"electronic","value":"1756-185X"}],"subject":[],"published":{"date-parts":[[2023,2,6]]},"assertion":[{"value":"2022-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}