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The primary and secondary outcomes included the relationship between targeted therapies and all cardiovascular events (CVEs), major adverse cardiovascular events (MACEs), myocardial infarction (MI), heart failure, and stroke in PsO\/PsA. The outcome risk ratios (RRs) were calculated using the Mantel\u2013Haenszel fixed\u2010effect method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 81 articles involving 88 RCTs were included. There was no statistically significant difference regarding the occurrence of all CVEs for all targeted therapies (RR\u00a0=\u00a01.03, 95% CI 0.74\u20101.43, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.85) compared to placebo in PsO\/PsA. No statistically significant difference existed between drugs and placebo in patients with PsA on all CVEs (RR\u00a0=\u00a00.81, 95% CI 0.48\u20101.36, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.43). Surprisingly, the incidence of all CVEs was higher in the low dosage group compared to the high dosage group of all targeted therapies (RR\u00a0=\u00a01.97, 95% CI 1.19\u20103.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) and prominently anti\u2010interleukin\u201017 agent (RR\u00a0=\u00a02.20, 95% CI 1.05\u20104.58, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current targeted therapies are not associated with the risk of CVEs. Based on the existing evidence, we reported here that a dosage reduction of targeted therapies was not recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14603","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T01:13:59Z","timestamp":1675991639000},"page":"625-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of targeted therapies on the risk of cardiovascular events in patients with psoriasis and psoriatic arthritis: A\u00a0systematic review and aggregate data meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4949-0923","authenticated-orcid":false,"given":"Ruyi","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Peking University Third Hospital  Beijing 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