{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:01:41Z","timestamp":1783479701507,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ozone therapy is a minimally invasive technique now widely used for the treatment of pain due to herniated discs. In literature there are conflicting results concerning its real effectiveness and few data about its possible complications. In this case report we present a case of spondylodiscitis, septic arthritis and gluteal abscess following the execution of 4 sessions of ozone therapy. Given the impossibility of isolating the etiological agent, an empirical antibiotic therapy with an overall duration of 6\u2009weeks was set up, initially with daptomycin and ceftriazone, to which was added after 2\u2009days metronidazole, administered intravenously; after 20\u2009days the cephalosporin was replaced with oral amoxicillin\/clavulanate. Neridronate was added to treat bone edema and to avoid bone erosion. The patient showed improvement of both clinical conditions and inflammation indexes, and was discharged after 4\u2009weeks without further complications at follow\u2010up. Few cases are reported in the literature about spondylodiscitis secondary to ozone treatment, and just 1 case is described about the use of neridronate as additive drug to antibiotic treatment in spondylodiscitis to avoid bone disruption and surgery complications.<\/jats:p>","DOI":"10.1111\/1756-185x.14632","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T06:38:25Z","timestamp":1677134305000},"page":"1590-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serious spondylodiscitis, septic sacroiliitis and multiple abscesses after ozone therapy for low back pain: A case report on good response to combined treatment with empiric antibiotic and neridronate"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-5941","authenticated-orcid":false,"given":"Francesca","family":"Erroi","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medical and Surgical Sciences University of Foggia \u2013 Policlinico Riuniti di Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-8423","authenticated-orcid":false,"given":"Cinzia","family":"Rotondo","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical and Surgical Sciences University of Foggia \u2013 Policlinico Riuniti di Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical and Surgical Sciences University of Foggia \u2013 Policlinico Riuniti di Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Trotta","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical and Surgical Sciences University of Foggia \u2013 Policlinico Riuniti di Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9929-9177","authenticated-orcid":false,"given":"Francesco Paolo","family":"Cantatore","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical and Surgical Sciences University of Foggia \u2013 Policlinico Riuniti di Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-1970","authenticated-orcid":false,"given":"Addolorata","family":"Corrado","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical and Surgical Sciences University of Foggia \u2013 Policlinico Riuniti di Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"issue":"19","key":"e_1_2_4_2_1","first-page":"6034","article-title":"Oxygen\u2010ozone therapy for the treatment of low back pain: a systematic review of randomized controlled trials","volume":"25","author":"Sconza C","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"3","key":"e_1_2_4_3_1","first-page":"172","article-title":"Ozone therapy for low back pain. A systematic review","volume":"43","author":"Costa T","year":"2018","journal-title":"Acta Reumatol Port"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_50_2020"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11420-016-9500-1"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000195"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318195a87e"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000254125.85406.6e"},{"issue":"2","key":"e_1_2_4_9_1","first-page":"117","article-title":"A systematic review: characteristics, complications and treatment of spondylodiscitis","volume":"23","author":"Gentile L","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"51","key":"e_1_2_4_10_1","first-page":"875","article-title":"Spondylodiscitis: diagnosis and treatment options","volume":"114","author":"Herren C","year":"2017","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-015-4318-y"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0460-0"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T03:59:28Z","timestamp":1692244768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/1756-185X.14632"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14632","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]},"assertion":[{"value":"2022-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}