{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:51:55Z","timestamp":1789685515967,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to show the effectiveness of interleukin (IL)\u201023 inhibitors in psoriatic arthritis (PsA) at weeks 12 and 24 in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010three patients with active PsA were enrolled in this study. These patients were treated with either guselkumab (<jats:italic>n<\/jats:italic>\u00a0=\u200920) or risankizumab (<jats:italic>n<\/jats:italic>\u00a0=\u200923). Treatment responses at the 12th and 24th weeks were evaluated with the parameters of the number of joints with active arthritis, Psoriasis Area Severity Index (PASI) response rate, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score, Disease Activity Index for Psoriatic Arthritis (DAPSA) score, and C\u2010reactive protein (CRP) value. The study's primary endpoint was BASDAI\u2009\u2264\u20094 and DAPSA\u2009\u2264\u200914 at week 24, and the secondary endpoint was the absence of joints with clinically active arthritis signs at week 24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u201023 inhibition significantly improved all treatment response parameters at the 12th and 24th weeks (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). While 90% of patients reached the primary endpoint with anti\u2010IL23 therapy, 74% achieved the secondary endpoint. Both biologic\u2010na\u00efve and biologic\u2010experienced patients responded significantly to anti\u2010IL\u201023 therapy. Also, no adverse events related to anti\u2010IL\u201023 agents were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The response parameters indicating the severity of PsA (the number of joints with active arthritis, BASDAI score, DAPSA score, and CRP value) and a parameter indicating the severity of skin involvement, that is, PASI score, significantly improved with anti\u2010IL\u201023 therapy at weeks 12 and 24. Moreover, significant improvement was achieved at week 24 compared to week 12 in all response parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14663","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T02:30:03Z","timestamp":1679020203000},"page":"878-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of <scp>anti\u2010interleukin<\/scp>\u201023 therapy in psoriatic arthritis: A pilot prospective real\u2010world study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-7638","authenticated-orcid":false,"given":"Tumay","family":"Ak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa  Istanbul 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