{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:18:41Z","timestamp":1789561121154,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Interstitial lung disease (ILD) is common in anti\u2010synthetase syndrome (ASS). Progressive fibrosing ILD (PF\u2010ILD) may develop in ILD with autoimmune features. Data on PF\u2010ILDs in ASS as a group are scarce. This study aimed to explore the characteristics and predictors of PF\u2010ILD in ASS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled 96 ASS\u2010ILD patients. Baseline clinical data were collected. PF\u2010ILD assessments were conducted at every hospital visit during windows of 24\u2009months after initial diagnosis. Phenotypic, survival features and predictors of PF\u2010ILD were estimated through SPSS 22.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results revealed that 35.42% (34\/96) were evaluated to be PF\u2010ILD with a median interval time of 14.73\u2009months. Nonspecific interstitial pneumonia was the most common radiological pattern of PF\u2010ILD. Ground glass opacity (GGO), traction bronchiectasis and reticulation were representative high\u2010resolution computed tomography findings of this group. Compared with the non\u2010progressive group, PF\u2010ILD patients had higher frequencies of anti\u2010Ro\u201052 antibodies (91.18% vs 66.13%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007) and GGO in the lower + middle and lower + middle + upper zones of the left lung, as well as lower + middle zones in the right lung (85.30% vs 54.84%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003; 64.71% vs 38.71%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.015; 82.35% vs 58.06%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.016). Multivariate Cox analysis identified that anti\u2010Ro\u201052 antibody (hazards ratio [HR] 3.55, 95% CI 1.06\u201311.90,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.040) and GGO in left lower + middle lung zones (HR 22.11, 95% CI 1.95\u2013250.90,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.012) were independent risk factors for PF\u2010ILD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PF\u2010ILD was associated with poor prognosis. Over one\u2010third of ASS\u2010ILD patients may develop to PF\u2010ILD. Anti\u2010Ro\u201052 antibody positivity and GGO in left lower + middle lung zones were independent risk factors for PF\u2010ILD in ASS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14664","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T05:25:41Z","timestamp":1679289941000},"page":"885-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictive factors for progressive fibrosing interstitial lung disease in anti\u2010synthetase syndrome"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5590-9022","authenticated-orcid":false,"given":"Yin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyuan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/77.1.1019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.03.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01399-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161480"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060442"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.03.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00363"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2019.10.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0325-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02718-2020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00692-2018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1647040"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.778649"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0180"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000212"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8112013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.09.020"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06404-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.09.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1560"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/315179"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb07010.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2015.10.010"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.089656"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600623791"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106134"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0884-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex077"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.03.004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.09.003"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.05.012"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.4.9308447"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0322-7"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051356"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3023-x"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14664","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:45:36Z","timestamp":1692711936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/1756-185X.14664"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14664","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]},"assertion":[{"value":"2022-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}