{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:32:35Z","timestamp":1784871155267,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Secukinumab (SEC) is an effective and widely used drug in psoriatic disease and axial spondyloarthritis. However, SEC has been found to be associated with inflammatory conditions and vasculitis. These inflammatory adverse effects may complicate the treatment of underlying disease, and clinicians may experience difficulties in recognizing and managing this unusual condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A man aged 56\u2009years with psoriatic disease refractory to conventional disease\u2010modifying antirheumatic drugs was given adalimumab for 6\u2009weeks, then switched to SEC when his psoriatic lesions were exacerbated. After 3\u2009weeks of SEC treatment, he developed systemic features of IgA vasculitis while his skin lesions and arthritis persisted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although SEC\u2010related inflammatory adverse events, including vasculitis, are rarely encountered in clinical practice, it is essential to recognize them because they can be mistaken as a component of the underlying inflammatory disease. In addition, the dramatic improvement in many cases after the cessation of SEC underlines the importance of making an accurate diagnosis. Pathogenetically, these adverse events are likely to be paradoxical reactions, except for SEC\u2010induced inflammatory bowel diseases. However, in many aspects, their pathogenesis is controversial and needs clarification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14667","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T02:18:25Z","timestamp":1679019505000},"page":"1811-1815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Secukinumab\u2010induced <scp>IgA<\/scp> vasculitis in a patient with psoriatic arthritis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-3144","authenticated-orcid":false,"given":"Rana Berru","family":"Ozince","sequence":"first","affiliation":[{"name":"Cerrahpasa Medical Faculty, Department of Internal Medicine Istanbul University\u2010Cerrahpasa  Istanbul 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