{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:14:31Z","timestamp":1790907271189,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The development of rheumatoid arthritis (RA) has been classified into 6 phases A\u2013F according to the present risk factors in sequence of genes, environments, autoimmunity, arthralgia and joint swelling. To clarify the ultrasound synovitis scores in at\u2010risk patients (phases C\u2013E) and RA (phase F).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who had been experiencing hand joint symptoms for at least 6\u2009weeks and asymptomatic patients with positive rheumatoid factor and\/or anti\u2010cyclic citrullinated peptide antibodies were enrolled. A 40\u2010joint ultrasonography with semiquantitative synovitis scoring for gray scale (GS) and power Doppler (PD) images was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 139 patients were enrolled and classified into non\u2010RA, phase C, phase D, phase E and phase F. Total GS scores in phases C (17.4\u2009\u00b1\u20097.0), D (16.0\u2009\u00b1\u20095.4), E (18.5\u2009\u00b1\u20097.7) and F (21.8\u2009\u00b1\u20099.1) were higher than those in non\u2010RA (9.8\u2009\u00b1\u20094.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The total PD score in phase F (3.1\u2009\u00b1\u20094.6) was higher than that in phases C (0.2\u2009\u00b1\u20090.5), D (0.1\u2009\u00b1\u20090.4), and E (0.1\u2009\u00b1\u20090.3), as well as in non\u2010RA (0.0\u2009\u00b1\u20090.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). A total GS score \u226514 differentiated patients at risk for RA from patients with non\u2010RA (area under curve [AUC] 0.82), while a total PD score \u22652 differentiated patients with RA from patients at risk for RA (AUC 0.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Total GS score may differentiate patients at risk for RA from non\u2010RA patients, while total PD score may differentiate patients with RA from those who are at risk for RA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14675","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T03:33:27Z","timestamp":1679456007000},"page":"922-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of ultrasound synovitis scores for patients who are at risk of rheumatoid arthritis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-2665","authenticated-orcid":false,"given":"Tsai\u2010Hung","family":"Yen","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Da","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-4587","authenticated-orcid":false,"given":"Hsin\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5948-7306","authenticated-orcid":false,"given":"Chih\u2010Wei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-3065","authenticated-orcid":false,"given":"Yi\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Lung","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University  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