{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:29:07Z","timestamp":1793464147540,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012351","name":"Mitsubishi Tanabe Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify risk factors for relapse after methotrexate (MTX) dose reduction in rheumatoid arthritis (RA) patients receiving golimumab (GLM)\/MTX combination therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data on RA patients \u226520\u2009years old receiving GLM (50\u2009mg)\u2009+\u2009MTX for \u22656\u2009months were retrospectively collected. MTX dose reduction was defined as a reduction of \u226512\u2009mg from the total dose within 12\u2009weeks of the maximum dose (\u22651\u2009mg\/wk average). Relapse was defined as Disease Activity Score in 28 joints using C\u2010reactive protein level (DAS28\u2010CRP) score\u2009\u22653.2 or sustained (\u2265 twice) increase of \u22650.6 from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 304 eligible patients were included. Among the MTX\u2010reduction group (<jats:italic>n<\/jats:italic>\u2009=\u2009125), 16.8% of patients relapsed. Age, duration from diagnosis to the initiation of GLM, baseline MTX dose, and DAS28\u2010CRP were comparable between relapse and no\u2010relapse groups. The adjusted odds ratio (aOR) of relapse after MTX reduction was 4.37 (95% CI 1.16\u201316.38, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) for prior use of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), and the aORs for cardiovascular disease (CVD), gastrointestinal disease and liver disease were 2.36, 2.28, and 3.03, respectively. Compared to the non\u2010reduction group, the MTX\u2010reduction group had a higher proportion of patients with CVD (17.6% vs 7.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and a lower proportion of prior use of biologic disease\u2010modifying antirheumatic drugs (11.2% vs. 24.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.0076).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Attention should be given to RA patients with history of CVD, gastrointestinal disease, liver disease, or prior NSAIDs\u2010use when considering MTX dose reduction to ensure benefits outweigh the risks of relapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14695","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T21:59:22Z","timestamp":1681509562000},"page":"1058-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors associated with relapse after methotrexate dose reduction in patients with rheumatoid arthritis receiving golimumab and methotrexate combination therapy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-6941","authenticated-orcid":false,"given":"Noboru","family":"Kitamura","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology and Rheumatology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Rheumatology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Rheumatology Nihon University School of Medicine  Tokyo 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