{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:52:51Z","timestamp":1785376371027,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Restless leg syndrome (RLS) is a neurological disorder characterized by an uncontrollable desire to move legs along with abnormal sensations, particularly at night, which can lead to sleep disturbance. RLS may mimic rheumatic diseases or can be associated with them, hence their identification and treatment are important to improve sleep quality and overall quality of life in rheumatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a search of the PubMed, SCOPUS, and EMBASE databases to identify studies reporting a prevalence of RLS in patients with rheumatic disease. Two authors independently screened, selected, and extracted the data. Heterogeneity was assessed using <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistics and random effect method of the meta\u2010analysis was used to synthesize the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 273 unique records, 17 eligible studies including 2406 rheumatic patients were identified. RLS prevalence (95% CI) among patients of rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, fibromyalgia and ankylosing spondylitis are found to be 26.6% (18.6 34.6); 32.5% (23.1\u201341.9), 4.4% (2.0\u20136.8), 38.1% (31.3\u201345.0) and 30.8% (23.48\u201339.16) respectively. RLS prevalence was similar for males and females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates a high prevalence of RLS in patients with rheumatic diseases. Early detection and treatment of RLS in patients with rheumatic conditions could be beneficial in improving their overall health and quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14710","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:40:07Z","timestamp":1683160807000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Restless leg syndrome in rheumatic conditions: Its prevalence and risk factors, a meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-9032","authenticated-orcid":false,"given":"Prasanta","family":"Padhan","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-8303","authenticated-orcid":false,"given":"Debashis","family":"Maikap","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Kalinga Institute of Medical Sciences, KIIT University  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-9890","authenticated-orcid":false,"given":"Mona","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy, College of Pharmacy University of North Texas Health Science Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.09.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp021288"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000054"},{"issue":"1","key":"e_1_2_10_5_1","article-title":"Which is the preferred measure of heterogeneity in meta\u2010analysis and why? 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