{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:53:58Z","timestamp":1770465238268,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our understanding of IgG4\u2010RD and pachymeningitis has grown substantially, but the optimal approach for diagnosis, management, and long\u2010term outcomes is still an area of uncertainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HUVAC is a database for IgG4\u2010RD patients, this database was retrospectively evaluated for pachymeningeal disease. Demographic, clinical, serological, imaging, histopathological data, and treatment details were re\u2010interpreted in patients with pachymeningitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 97 patients with IgG4\u2010RD, 6 (6.2%) had pachymeningitis. None of these patients had extracranial features, and also, in most of the patients, serum IgG4 levels were normal. Tentorium cerebelli and transverse sinus dura were the most commonly involved in the posterior fossa. During 18 months of median follow\u2010up on steroid+\u2010rituximab, none of them relapsed as pachymeningitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our patients were mainly older males with sole neurological involvement. Non\u2010specific headache was the most common manifestation, and serum IgG4 levels were not useful for diagnosis. Typical radiology and tentorial thickening should suggest IgG4\u2010RD and prompt an early biopsy. Moreover, accompanying hypophysitis could also be a clue. With steroids+ rituximab treatment, no relapse related to meningeal involvement was seen in long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14725","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T12:05:01Z","timestamp":1688558701000},"page":"1853-1860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>IgG4\u2010related<\/scp> pachymeningitis\u2014Long term follow up and outcome of six patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9543-4685","authenticated-orcid":false,"given":"Gozde Kubra","family":"Yardimci","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hacettepe University School of Medicine  Ankara Turkey"},{"name":"Vasculitis Research Centre Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doruk","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"Babao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-2813","authenticated-orcid":false,"given":"Ertu\u011frul Cagri","family":"Bolek","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hacettepe University School of Medicine  Ankara Turkey"},{"name":"Vasculitis Research Centre Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Kilic","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hacettepe University School of Medicine  Ankara Turkey"},{"name":"Vasculitis Research Centre Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Saglam","sequence":"additional","affiliation":[{"name":"Department of Pathology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asl\u0131","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"S\u00f6ylemezo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rah\u015fan","family":"Gocmen","sequence":"additional","affiliation":[{"name":"Department of Radiology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kader K.","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Radiology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Karadag","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Hacettepe University School of Medicine  Ankara Turkey"},{"name":"Vasculitis Research Centre Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-017-0450-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-011-0571-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117420"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000680"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39205"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.05.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.243"},{"issue":"8","key":"e_1_2_6_10_1","first-page":"763","article-title":"Hypertrophic pachymeningitis associated with autoimmune pancreatitis examined for IgG4 related disease: a case report","volume":"39","author":"Kato K","year":"2011","journal-title":"No Shinkei Geka"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6604"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121545"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000568"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-5-201203060-00025"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.10.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2015-001275"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000488"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3950"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:47:37Z","timestamp":1693817257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,5]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/1756-185X.14725"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14725","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,5]]},"assertion":[{"value":"2023-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}