{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:54:35Z","timestamp":1790189675530,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Lupus nephritis (LN) is a common type of organ damage which occurs in SLE patients and is characterized by recurrent proteinuria. Activation of B lymphocytes can lead to refractory LN, which is an important pathogenic factor in SLE. B lymphocyte stimulator (BLyS) and A proliferation\u2010inducing ligand (APRIL) are predominantly produced by myeloid cells (monocytes, dendritic cells, neutrophils, etc) to regulate B lymphocyte function. Telitacicept was the first dual\u2010targeting biological drug which targeted both BLyS and APRIL. Telitacicept has passed a phase II clinical trial and has since been approved for the treatment of SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We report a case of SLE confirmed by renal biopsy as proliferative lupus nephritis (PLN) with massive proteinuria, which was treated with telitacicept (European League Against Rheumatism \/ American College of Rheumatology 2019 standard). During the 19\u2009months of follow\u2010up, the patient's renal function was stable, massive proteinuria was relieved, and creatinine and blood pressure did not increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During the 19\u2009months of telitacicept treatment (160\u2009mg once weekly), PLN reduced blood system damage and proteinuria without increasing the risk of infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14752","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T09:34:16Z","timestamp":1684834456000},"page":"1417-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A patient with refractory proliferative lupus nephritis treated with telitacicept: A case report"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-8694","authenticated-orcid":false,"given":"Jing\u2010Wen","family":"Chen","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Yi","family":"Zhan","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou 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Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-6127","authenticated-orcid":false,"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou 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