{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:06:53Z","timestamp":1781712413101,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastrointestinal manifestations are a very rare complication of dermatomyositis (DM) and are much less frequent in adult cases than in juvenile cases. Only a few previous papers have reported adult patients who had DM with anti\u2010nuclear matrix protein 2 (anti\u2010NXP2) antibodies and who developed gastrointestinal ulcers. Herein, we report a similar case of a 50\u2010year\u2010old man who had DM with anti\u2010NXP2 antibodies followed by relapsing multiple gastrointestinal ulcers. Even after the administration of prednisolone, his muscle weakness and myalgia deteriorated and gastrointestinal ulcers relapsed. In contrast, intravenous immunoglobulin and azathioprine improved his muscle weakness and gastrointestinal ulcers. Based on the parallel disease activity of the muscular and gastrointestinal symptoms, we considered that his gastrointestinal ulcers were a complication of DM with anti\u2010NXP2 antibodies. We also propose that early intensive immunosuppressive therapy would be required for the muscular and gastrointestinal symptoms in DM with anti\u2010NXP2 antibodies.<\/jats:p>","DOI":"10.1111\/1756-185x.14755","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:21:10Z","timestamp":1686205270000},"page":"2572-2575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2010nuclear matrix protein 2 antibody\u2010positive dermatomyositis with gastrointestinal ulcers: A case report"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-9741","authenticated-orcid":false,"given":"Naohiro","family":"Uchio","sequence":"first","affiliation":[{"name":"Department of Neurology Mitsui Memorial Hospital  Tokyo 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