{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:29:37Z","timestamp":1786562977233,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Joint symptoms associated with gout, mostly characterized by joint flare\u2010ups, are well known. Tophi represent the main cutaneous manifestation of gout, most often associated with a chronic and inadequately controlled disease. On rare occasions, atypical skin manifestations may occur. We present the case of a miliary form of gout in a 36\u2010year\u2010old man known to have hyperuricemia. Microscopic direct analysis of the skin material revealed the presence of monosodium urate (MSU) crystals. Rash disappeared with corticosteroid therapy in parallel with joint symptoms recovery. Knowledge of this unusual gout\u2010related skin disease is essential to diagnosing uncommon presentations of gout, which sometimes occur before joint symptoms. This case highlights the importance of sampling any skin lesion suspected of being tophus, for MSU crystal identification, and provides a definitive diagnosis.<\/jats:p>","DOI":"10.1111\/1756-185x.14763","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:34:35Z","timestamp":1686191675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From skin to microscope, case report of a rare manifestation of tophaceous gout: Miliary gout"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-7421","authenticated-orcid":false,"given":"Cavillon","family":"Th\u00e9au","sequence":"first","affiliation":[{"name":"Department of Rheumatology, CHU Rennes, H\u00f4pital sud  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-5799","authenticated-orcid":false,"given":"Berthe","family":"Pauline","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Rennes, Pontchaillou  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chotard","family":"Emilie","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU Rennes, H\u00f4pital sud  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-1824","authenticated-orcid":false,"given":"Guggenbuhl","family":"Pascal","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU Rennes, H\u00f4pital sud  Rennes France"},{"name":"Inserm UMR 1241, Inra, Institut NUMECAN (Nutrition Metabolism and Cancer)  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-8160","authenticated-orcid":false,"given":"Robin","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU Rennes, H\u00f4pital sud  Rennes France"},{"name":"Inserm UMR 1241, Inra, Institut NUMECAN (Nutrition Metabolism and Cancer)  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.01.002"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"27","article-title":"Gout: state of the art after a decade of developments","volume":"58","author":"Pascart T","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39254"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.36.1.91"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1561-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.07.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2007.00002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-009735"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12084"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3261047184"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2014.14106"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcw169"},{"issue":"25","key":"e_1_2_8_14_1","first-page":"1339","article-title":"Disseminated skin abnormalities due to gout","volume":"143","author":"Bruin\u2010Weller MS","year":"1999","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.05.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13235"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:56:08Z","timestamp":1786560968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/1756-185X.14763"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14763","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"2023-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14763"}}