{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:49:21Z","timestamp":1789148961099,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pyoderma gangrenosum (PG) is a rare autoinflammatory disorder falling under the spectrum of neutrophilic dermatosis, characterized by distinctive skin ulceration which is non\u2010infective, non\u2010neoplastic and usually with no primary vasculitis. PG lesions are notorious for relapse and hence require multiple trials of medications often with prolonged and concomitant use of steroids. Due to lack of evidence\u2010based studies on effective treatment options for PG, we have presented three isolated biopsy\u2010proven PG cases who were successfully treated with Tofacitinib, a Janus kinase\/signal transducers and activators of transcription (JAK\/STAT) pathway inhibitor, without relapse in follow up.<\/jats:p>","DOI":"10.1111\/1756-185x.14810","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:54:19Z","timestamp":1688370859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tofacitinib in pyoderma gangrenosum \u2013 A case series"],"prefix":"10.1111","volume":"27","author":[{"given":"Vanitha Agrahara","family":"Sathyanarayana","sequence":"first","affiliation":[{"name":"Department of Rheumatology Divisha Arthritis and Medical Center  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-545X","authenticated-orcid":false,"given":"Debaditya","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology Institute of Postgraduate Medical Education and Research (IPGMER)  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavya","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Chord Road Hospital  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K. R.","family":"Rao","sequence":"additional","affiliation":[{"name":"Divisha Arthritis and Medical Center  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"315","article-title":"Pyoderma gangrenosum: a challenge to the rheumatologist\u2010bras","volume":"49","year":"2009","journal-title":"J Rheumatol"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00699-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-3-224"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11595240-000000000-00000"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14683"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1506083"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.10.047"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00767-7"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:56:01Z","timestamp":1786560961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/1756-185X.14810"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14810","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,3]]},"assertion":[{"value":"2023-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14810"}}