{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:30:14Z","timestamp":1786563014792,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human immunodeficiency virus (HIV) infection is associated with a myriad of musculoskeletal manifestations. Inflammatory arthritis has been described in association with HIV in both adults and children. Biologic disease\u2010modifying anti\u2010rheumatic drugs, particularly tumor necrosis factor inhibitors (TNFi), have been reported to manage inflammatory arthritis in adults with HIV when conventional therapy fails to control arthritis. In this report, we describe the management of arthritis and enthesitis in a 12\u2010year\u2010old adolescent male with HIV using the TNFi adalimumab. At the time of presentation, the patient was on highly active antiretroviral therapy for 1\u2009year. His viral load was &lt;40\u2009copies\/mL, and the CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell count was 1280\u2009cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    . He had a positive antinuclear antibody and HLA\u2010B27. Rheumatoid factor was negative. After screening for hepatitis B and C and latent tuberculosis, the patient was started on adalimumab. This report describes the successful control of recalcitrant arthritis and enthesitis in a pediatric patient with HIV infection using adalimumab.\n                  <\/jats:p>","DOI":"10.1111\/1756-185x.14827","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T05:40:55Z","timestamp":1689054055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The use of a tumor necrosis factor inhibitor\u2014adalimumab\u2014in the management of arthritis in an adolescent with\n                    <scp>HIV<\/scp>\n                    : A case report"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-2164","authenticated-orcid":false,"given":"Reima","family":"Bakry","sequence":"first","affiliation":[{"name":"Department of Pediatrics East Jeddah Hospital  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0789-4372","authenticated-orcid":false,"given":"Nada","family":"Bokhary","sequence":"additional","affiliation":[{"name":"Department of Pediatrics East Jeddah Hospital  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7320-5320","authenticated-orcid":false,"given":"Esraa","family":"Sendi","sequence":"additional","affiliation":[{"name":"College of Medicine Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-4045","authenticated-orcid":false,"given":"Malak","family":"Alshehri","sequence":"additional","affiliation":[{"name":"College of Medicine Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1669-8397","authenticated-orcid":false,"given":"Lama","family":"Sindi","sequence":"additional","affiliation":[{"name":"College of Medicine Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6396-9263","authenticated-orcid":false,"given":"Hend","family":"Alkwai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine University of Ha'il  Ha'il Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"UNAIDS.Global HIV & AIDS statistics: fact sheet 2022. Accessed January 1 2023.https:\/\/www.unaids.org\/en\/resources\/fact\u2010sheet"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05500-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41802"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.677984"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.35"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2018.18045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101392"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.4.350-b"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130896"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100713"},{"issue":"9","key":"e_1_2_10_12_1","first-page":"1578","article-title":"Rheumatologic manifestations of pediatric human immunodeficiency virus infection","volume":"20","author":"Schuval SJ","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/108729101753205685"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.10.1093"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.081513"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002282"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"285","article-title":"Refractory psoriatic arthritis and polyarteritis nodosa: co\u2010occurrence in a patient with undiagnosed HIV","volume":"81","author":"Awan S","year":"2017","journal-title":"Conn Med"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3690-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.942642"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh636"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23870"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14827","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:58:04Z","timestamp":1786561084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/1756-185X.14827"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14827","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"2023-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14827"}}