{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:19:44Z","timestamp":1773249584023,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the rapidity of magnetic resonance imaging (MRI) measured synovitis (as measured by synovial thickening using the RAMRIS\u2010SAFE score) and bone edema in active rheumatoid arthritis (RA) subjects treated with golimumab. Secondary aims: to correlate MRI measures with disabilities of the arm, shoulder, and hand (DASH), physician global (PhysG) and patient global (PatG) assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with active RA and inadequate response to methotrexate were recruited. Active RA was defined as RA with a Disease Activity Score of 28 joints \u2013 C\u2010reactive protein \u22654.2 at screening AND active disease (synovitis and edema) of the chosen hand or wrist on MRI at screening, as determined by the central blinded MRI reader (PB). Outcomes measures were assessed at baseline, 2, 6, and 12\u2009weeks. MRI results were interpreted by one experienced observer (PB), blinded to clinical measures. Pearson's correlation co\u2010efficient (SPSS) was used to express the relationship between DASH, PhysG, PatG and MRI measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients were included in the study. All subjects completed follow\u2010up visits and MRI assessment. Mean age was 60.6\u2009years (range 22\u201372), and 10 were female, 8 male, and disease duration was mean 4.72\u2009years (range 1\u201328); all patients were taking background methotrexate. The changes in MRI synovial volume were evident by visit 2. The strongest correlations with the DASH for MRI parameters were total synovial thickening (0.923) and edema (0.921).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Golimumab was associated with rapid improvement in clinical measures and patient\u2010reported outcome measures. Mean synovial thickening demonstrated early rapid improvement. MRI synovial thickening demonstrated a strong correlation with DASH, PatG and PhysG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14847","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T13:34:23Z","timestamp":1690983263000},"page":"1960-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Magnetic resonance imaging RAMRIS\u2010SAFE score\u2014A low\u2010risk effective measure of rapid response to therapy in rheumatoid arthritis clinical trials"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-8337","authenticated-orcid":false,"given":"Paul","family":"Bird","sequence":"first","affiliation":[{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Needham","sequence":"additional","affiliation":[{"name":"Emeritus Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Spiers","sequence":"additional","affiliation":[{"name":"Janssen\u2010Cilag Pty Ltd  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hall","sequence":"additional","affiliation":[{"name":"Emeritus Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205302"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-2000-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.suppl_1.i28"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000057"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206359"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.146068"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204762"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161433"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25625"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090350"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3522-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12020465"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu029"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110978"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-006-0129-x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185118773507"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.115493"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:57:19Z","timestamp":1697068639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/1756-185X.14847"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14847","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"2023-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}