{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:28Z","timestamp":1747182628099,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010melanoma differentiation\u2010associated gene 5 (MDA5) dermatomyositis is characterized by serological detection of anti\u2010MDA5 antibody and rapidly progressive interstitial lung disease. In this study, the largest cohort of skin biopsies to date of anti\u2010MDA5 dermatomyositis was reviewed and compared with cases of dermatomyositis with negative serology. Findings contribute to the histological diagnosis and evaluation of the severity of cutaneous inflammation in anti\u2010MDA5 dermatomyositis. Skin biopsies collected over a 7\u2010year period from individuals with clinically and histologically confirmed dermatomyositis with anti\u2010MDA5 serology were reviewed. A total of 46 cases with 17 anti\u2010MDA5 positive cases were retrieved. Patients with positive antibody were younger (53.7 vs. 60.6\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u2009.013). No differences in epidermal changes (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05) were observed. Pertaining to interface changes, anti\u2010MDA5 dermatomyositis showed a higher degree of pigmentary incontinence (<jats:italic>p<\/jats:italic>\u2009=\u2009.014), suggesting increased and sustained cutaneous inflammation. Periodic acid\u2013Schiff (PAS) stain demonstrated a greater degree of basement membrane thickening (<jats:italic>p<\/jats:italic>\u2009=\u2009.045). Other parameters, including dermal inflammation, dermal mucin deposition and vasculitic\/vasculopathic features did not show statistical difference between anti\u2010MDA5 positive and negative dermatomyositis (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Findings suggest increased cutaneous inflammation for anti\u2010MDA5 dermatomyositis. In skin biopsies, marked pigmentary incontinence or basement membrane thickening should raise suspicion of anti\u2010MDA5 dermatomyositis.<\/jats:p>","DOI":"10.1111\/1756-185x.14866","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T07:05:55Z","timestamp":1691996755000},"page":"2031-2036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased histological severity and chronicity of interface inflammation in anti\u2010<scp>MDA5<\/scp> dermatomyositis\u2014A comparative dermatopathological analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Agnes Wai Sze","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Medicine and Therapeutics, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Man\u2010Tung","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Medicine and Therapeutics, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla Ching\u2010Han","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Medicine and Therapeutics, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Cheung Lung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna Ka Man","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-0314","authenticated-orcid":false,"given":"Joshua Jing Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong 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