{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:19:38Z","timestamp":1782951578612,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There have been major changes in the classification and treatment of patients with idiopathic inflammatory myositis (IIM) in the last 2 decades. A major challenge is to identify the parameters that can affect the outcome and prognosis of these patients. Here, we have longitudinally followed a well\u2010characterized cohort of IIM patients in a rheumatology center and reported the outcome using the validated tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with a clinical diagnosis of IIM and a follow\u2010up duration of greater than 2\u2009years were prospectively included in the study. The duration of the study was 6\u2009years: July 2016\u2013July 2022. Clinical details and follow\u2010up were recorded using pro\u2010formas and outcomes were noted using validated tools. Ethics approval and written informed consent were taken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty patients had a clinical diagnosis of IIM. Mean follow\u2010up duration was 43.8 (15) months. Out of 40 patients, 32 (80%) achieved remission (8 patients each were off corticosteroid and off treatment for &gt;6\u2009months), 5 (12%) expired and 3 (8%) had active disease. Disease course was non\u2010relapsing in 22\/35 (73%) patients. Mean manual muscle testing\u20108 score (<jats:italic>n<\/jats:italic>\u2009=\u200929) and myositis disease activity assessment tool score (<jats:italic>n<\/jats:italic>\u2009=\u200935) at the final visit were 75.6 (6.8) and 0.048 (0.07) respectively. Thirteen patients had damage (37%). Patients with disease duration &gt;1 year at the time of presentation were more likely to develop chronic\u2010continuous disease course (<jats:italic>P<\/jats:italic>\u2009=\u2009.023, odds ratio [OR]\u2009=\u20097.6), more frequently required second\u2010line or third\u2010line immunosuppression (<jats:italic>P<\/jats:italic>\u2009=\u2009.001, OR\u2009=\u200924) with higher myositis damage index score (<jats:italic>p<\/jats:italic>\u2009=\u2009.0002, OR\u2009=\u200947).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IIM patients had good outcomes with the majority achieving remission and near\u2010complete muscle recovery. However, the patients presenting late to the rheumatologists were more likely to have smoldering disease, more immunosuppressive medicines, and greater accumulated damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14903","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:47:58Z","timestamp":1694166478000},"page":"2163-2169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Observational longitudinal study to assess the outcome of patients with idiopathic inflammatory myositis using validated tools"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-6763","authenticated-orcid":false,"given":"Anuj","family":"Shukla","sequence":"first","affiliation":[{"name":"Niruj Rheumatology Clinic  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-2180","authenticated-orcid":false,"given":"Priyanka","family":"Gaur","sequence":"additional","affiliation":[{"name":"Niruj Rheumatology Clinic  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1465-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000365"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.1.22"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13352"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-143"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211868"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/486yh4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140210"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000109755.65914.5e"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab015"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.74190"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3933.ijam20190543"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13759"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.338646"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-013-0260-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0030-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.10.014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000996"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab001"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/injr.injr_132_22"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/injr.injr_28_20"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000507"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0180"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh404"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39466"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.12.007"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001214"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.41"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T16:22:51Z","timestamp":1698855771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/1756-185X.14903"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14903","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"assertion":[{"value":"2023-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}