{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:51:12Z","timestamp":1790419872000,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the risk of all\u2010cause, specific mortality among patients with fibromyalgia, which is a controversial topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a thorough search for cohort studies across the PubMed, Cochrane Library, and Embase databases, from their inception to 1 March 2023, using medical subject headings and relevant keywords. All data were meticulously analyzed using Stata statistical software version 16.0. The protocol was registered on PROSPERO (CRD42023402337).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After analyzing seven cohort studies involving 152\u2009933 individuals published between 2001 and 2020, we found no clear evidence linking fibromyalgia or widespread pain to all\u2010cause mortality risk (odds ratio [OR] 1.11, 95% confidence interval [CI] 0.81\u20131.53; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200982.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.505). However, our subgroup analysis revealed that the risk of suicide was significantly higher in fibromyalgia patients compared with non\u2010fibromyalgia patients (OR 5.39, 95% CI 2.16\u201313.43; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200969.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our research did not discover any proof indicating a link between fibromyalgia or widespread pain and all\u2010cause mortality. However, it is worth noting that there may be a potential correlation between individuals with fibromyalgia or widespread pain and a higher likelihood of suicide. As we had a limited number of participants in our study, further research is necessary to thoroughly investigate the relationship between these factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14905","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T10:26:00Z","timestamp":1699266360000},"page":"2402-2409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fibromyalgia and risk of all\u2010cause, specific mortality: A meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0111-2130","authenticated-orcid":false,"given":"Hongli","family":"Wang","sequence":"first","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanlin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengping","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"He","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"1065","article-title":"Fibromyalgia: one year in review 2022","volume":"40","author":"Giorgi V","year":"2022","journal-title":"Clin Exp Rheumatol"},{"issue":"12","key":"e_1_2_10_3_1","first-page":"3070","article-title":"Fibromyalgia pathophysiology","volume":"10","author":"Gyorfi M","year":"2022","journal-title":"Biomedicine"},{"issue":"1","key":"e_1_2_10_4_1","article-title":"Physical activity and exercise for chronic pain in adults: an overview of Cochrane reviews","volume":"1","author":"Geneen LJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.22"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"1210","article-title":"Is thyroid autoimmunity a predisposing factor for fibromyalgia? 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