{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:29:50Z","timestamp":1786562990301,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n A 35\u2010year\u2010old male patient presented fluctuating bilateral lower extremity weakness for 3\u2009years. Physical examination showed grade 4 proximal muscle weakness in both lower extremities and grade 5 distal muscle weakness. Laboratory data revealed elevated creatine kinase, triglycerides, and cholesterol. Muscle pathology showed deposition of lipid droplet under the sarcolemma. Bone densitometry indicated severe osteoporosis. Next\u2010generation sequencing revealed a pathogenic mutation in the ETFDH gene. The patient was diagnosed with late\u2010onset multiple acyl\u2010CoA dehydrogenase deficiency. After riboflavin treatment, symptoms\u00a0of the patient were relieved, physical endurance was restored, and bone mineral density was improved.<\/jats:p>","DOI":"10.1111\/1756-185x.14906","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T06:35:47Z","timestamp":1695364547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report on multiple acyl\u2010\n CoA<\/scp>\n dehydrogenase deficiency with severe myopathy and osteoporosis"],"prefix":"10.1111","volume":"27","author":[{"given":"Man","family":"Li","sequence":"first","affiliation":[{"name":"The Second Hospital of Longyan Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7872-5983","authenticated-orcid":false,"given":"Zong\u2010Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2107-8918","authenticated-orcid":false,"given":"Ying\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Lin","sequence":"additional","affiliation":[{"name":"The Second Hospital of Longyan Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Xin","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Hospital of Longyan Longyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-0679","authenticated-orcid":false,"given":"James Cheng\u2010Chung","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan"},{"name":"Department of Allergy, Immunology & Rheumatology Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.04.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2009.05.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1730978"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12844"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2763"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-018-9460-5"}],"container-title":["International Journal of Rheumatic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1756-185X.14906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1756-185X.14906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:56:58Z","timestamp":1786561018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1756-185X.14906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/1756-185X.14906"],"URL":"https:\/\/doi.org\/10.1111\/1756-185x.14906","archive":["Portico"],"relation":{},"ISSN":["1756-1841","1756-185X"],"issn-type":[{"value":"1756-1841","type":"print"},{"value":"1756-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]},"assertion":[{"value":"2023-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14906"}}