{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:30:35Z","timestamp":1747182635591,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To investigate the radiological and laboratory features of bone and cartilage losses in premenopausal women with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study is the continuation of a study that was conducted on 48 women with RA and 48 matched healthy volunteers. All RA patients were previously subjected to clinical examination, disease activity assessment using the 28\u2010joint Disease Activity Score (DAS28) and Clinical Disease Activity Index (CDAI), serological tests, dual\u2010energy X\u2010ray absorptiometry measuring bone mineral density (BMD), and plain X\u2010ray of both hands. Added to these, matrix metalloproteinase 3 (MMP\u20103) and cartilage oligomeric matrix protein (COMP) were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were statistically significant differences between patients and controls regarding COMP and MMP\u20103, being higher in patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). COMP and MMP\u20103 have significant positive correlation with serum levels of anti\u2010cyclic citrullinated peptide (anti\u2010CCP) and anti\u2010carbamylated protein (anti\u2010CarP). The original Sharp erosion score was positively correlated with the serum level of the studied antibodies and disease duration, but no significant correlation was found with either COMP, MMP\u20103, or DAS\u201028. Spine BMD and <jats:italic>Z<\/jats:italic> score were negatively correlated with disease activity and anti\u2010CarP. There were significant positive relationhsips between indices of local cartilage and bone loss and the indices of systemic bone loss. MMP\u20103 had no correlation with indices of local cartilage and bone loss and disease activity scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pathogenic mechanism of hand joint damage involved the three studied autoantibodies namely, rheumatoid factor, anti\u2010CCP and anti\u2010CarP antibodies. Anti\u2010CarP antibody was involved in the reduction of BMD of the spine. The association between systemic osteoporosis and hand joint damage pointed to a common pathogenic mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14915","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:40:25Z","timestamp":1695274825000},"page":"2195-2205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cartilage and bone loss in premenopausal women with rheumatoid arthritis: Radiological and laboratory assessments"],"prefix":"10.1111","volume":"26","author":[{"given":"Noha A.","family":"Elsawy","sequence":"first","affiliation":[{"name":"Department of Physical Medicine Rheumatology and Rehabilitation Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A.","family":"Ghazala","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-4937","authenticated-orcid":false,"given":"Rehab","family":"Elnemr","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine Rheumatology and Rehabilitation Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.17354\/ijss\/2016\/193"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133858"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086348"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1319-x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.124"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.04.006"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207871"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11176"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2655"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740310002498"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa549"},{"key":"e_1_2_14_13_1","unstructured":"MedCalc Software.MedCalc statistical software version 12.4.0. 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