{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:28:59Z","timestamp":1787689739767,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>According to reports, long non\u2010coding RNAs (lncRNAs) are involved in the regulation of many inflammatory diseases. Here, our main purpose was to ascertain the expression data of lncRNA SNHG14 in acute gouty arthritis (AGA) and to explore its possible mechanism in the regulation of AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Reverse transcription quantitative polymerase chain reaction technology was supplied to detect the lncRNA SNHG14 expression. A receiver operating characteristics curve was drawn to estimate the accuracy of lncRNA SNHG14 in AGA diagnosis. An in vitro AGA cell model was constructed by inducing THP\u20101 cells with monosodium urate (MSU). The concentrations of inflammatory factors such as interleukin\u20101\u03b2, interleukin\u20106, and tumor necrosis factor\u2010\u03b1 were measured by enzyme\u2010linked immunosorbent assay. The luciferase reporter gene was used to verify the relationship between lncRNA SNHG14 and miR\u2010223\u20103p.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In clinical analysis, the levels of serum lncRNA SNHG14 in AGA patients were significantly higher than those in the control group. Abnormally elevated lncRNA SNHG14 has high sensitivity and specificity for AGA diagnosis. In in vitro cell experiments, silencing lncRNA SNHG14 inhibited the inflammatory response of THP\u20101 cells stimulated by MSU, and the luciferase reporter gene proved that lncRNA SNHG14 could bind to miR\u2010223\u20103p. In addition, the level of miR\u2010223\u20103p declined in AGA patients and the AGA cell model. Overexpression of miR\u2010223\u20103p is helpful to alleviate an MSU\u2010induced inflammatory response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the AGA cell model, lncRNA SNHG14, as an miR\u2010223\u20103p sponge, induces a cellular inflammatory response by controlling the level of miR\u2010223\u20103p, so aggravating the disease progress of AGA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14919","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T04:42:16Z","timestamp":1694839336000},"page":"2233-2239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Highly expressed long non\u2010coding <scp>RNA SNHG14<\/scp> activated <scp>MSU<\/scp>\u2010induced inflammatory response in acute gout arthritis through targeting miR\u2010223\u20103p"],"prefix":"10.1111","volume":"26","author":[{"given":"Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Clinical Research Center Shanghai Baoshan Luodian Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Research Center Shanghai Baoshan Luodian Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Clinical Research Center Shanghai Baoshan Luodian Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shili","family":"Xiong","sequence":"additional","affiliation":[{"name":"Clinical Research Center Shanghai Baoshan Luodian Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department 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