{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:07:13Z","timestamp":1778987233304,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873876"],"award-info":[{"award-number":["81873876"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>CD226 is widely expressed on the surface of immune cells as a co\u2010stimulatory receptor, which is involved in the development of many autoimmune diseases. The purpose of this study was to investigate the proportion of CD226 on CD14\u2009+\u2009monocytes in the peripheral circulation of patients with primary Sj\u00f6gren's syndrome (pSS) and the clinical significance of pSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The proportion of CD226 on the surface of CD14\u2009+\u2009monocytes was measured by flow cytometry in 45 pSS patients and 25 healthy controls (HC). The correlations between the proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes and the clinical features and laboratory parameters of pSS were analyzed. Meanwhile, we analyzed the change in proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes before and after treatment, and the clinical significance of pSS was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of CD226 on CD14\u2009+\u2009monocytes markedly increased in pSS patients compared to HC (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). We found the proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes was positively correlated with the disease activity and severity of pSS patients. The proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes in pSS patients with decayed tooth, fatigue, interstitial lung disease (ILD), low WBC, high IgG, anti\u2010Ro60, and anti\u2010SSB positive increased compared to that in negative patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Furthermore, the proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes was significantly higher in active patients than in nonactive patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Additionally, the proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes decreased in seven pSS patients after treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggested that an increased CD226 proportion on CD14\u2009+\u2009monocytes was associated with the clinical manifestations, disease activity, and prognosis of pSS patients. CD226+ CD14\u2009+\u2009monocytes may present a potential target and a biomarker for the prognosis and therapy of pSS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14936","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T16:44:20Z","timestamp":1696437860000},"page":"2460-2469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased proportion of CD226\u2009+\u2009CD14\u2009+\u2009monocytes correlates with clinical features and laboratory parameters in patients with primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"26","author":[{"given":"Ping","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Rheumatology The First Affiliated Hospital of Bengbu Medical College  Bengbu 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