{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T21:08:12Z","timestamp":1786655292949,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study aimed to compare the efficacy of non\u2010loading versus loading low\u2010dose colchicine in patients with acute crystal\u2010associated arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>All in\u2010patients who were admitted to Chiang Mai University Hospital with non\u2010arthritis disease and developed acute crystal\u2010associated arthritis during admission (within 48\u2009h after arthritis onset) were invited to join this study. The patients were randomized into two groups. Patients in Group I (non\u2010loading group) and Group II (loading group) received colchicine at 1.2 and 2.4\u2009mg in the first 24\u2009h, respectively. The primary outcome was the patients' pain response at 24\u2009h after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 80 patients, 49 were acute gouty arthritis, and 31 acute calcium pyrophosphate (CPP) arthritis. The mean [95% CI] pain score was no different between Groups I and II at the baseline level (6.46[5.72\u20137.19] vs. 6.654[5.85\u20137.44], <jats:italic>p<\/jats:italic>\u2009=\u2009.867) and at 24\u2009h (3.13[2.43\u20133.82] vs. 3.18[2.42\u20133.93], <jats:italic>p<\/jats:italic>\u2009=\u2009.907). The proportion of patients with \u226550% pain reduction was not different (57.50% vs. 55.00%, <jats:italic>p<\/jats:italic>\u2009=\u2009.822). Sensitivity analysis among patients with a baseline pain score of \u22654 showed the same pattern of response. Mild diarrhea was common and comparable in both groups. Subgroup analysis according to renal function (eGFR\u2009&lt;\u200960 vs. \u226560\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>) or type of crystals (acute gouty arthritis vs. acute CPP arthritis) also showed the same pattern of response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010loading low\u2010dose colchicine was as effective as loading low\u2010dose colchicine in patients with acute crystal\u2010associated arthritis, regardless of renal function or type of crystals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14943","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:11:54Z","timestamp":1697793114000},"page":"2478-2488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Non\u2010loading versus loading low\u2010dose colchicine in acute crystal\u2010associated arthritis: A double\u2010blinded randomized controlled study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2910-294X","authenticated-orcid":false,"given":"Ployrung","family":"Laosuksri","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Department of Internal Medicine Sawanpracharak Hospital  Nakorn Sawan Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4990-0489","authenticated-orcid":false,"given":"Nathrudee","family":"Phrintrakul","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Lanna Hospital  Chiang Mai Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6097-6064","authenticated-orcid":false,"given":"Wanitcha","family":"Gumtorntip","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8363-941X","authenticated-orcid":false,"given":"Kittiya","family":"Na\u2010Nan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-8190","authenticated-orcid":false,"given":"Antika","family":"Wongthanee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1150-6424","authenticated-orcid":false,"given":"Nuntana","family":"Kasitanon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-6122","authenticated-orcid":false,"given":"Worawit","family":"Louthrenoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.04.010"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket265"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06148-5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-008-0036-3"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27327"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03120080059008"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1987.tb01232.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23607"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41247"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055269"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209707"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14266"},{"key":"e_1_2_14_14_1","unstructured":"Thai Rheumatism Association.Guideline for management of gout.2012. 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