{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:29:46Z","timestamp":1788827386485,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to assess the association of obesity and CRP concentrations in adult patients with rheumatoid arthritis (RA), and its influence on measures of disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search was performed using Scopus, Web of Science, MEDLINE, and EMBASE, from the time of their inception to November 2021. Observational studies that evaluated the association between CRP concentrations and obesity or overweight in patients with RA were considered eligible. Correlation coefficients were pooled using the inverse variance method, while effect sizes were pre\u2010calculated for adjusted standardized regression coefficients (\u03b2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 studies, which comprised 4024 patients, were included in this systematic review. Individually, most studies report a significant association between CRP concentrations and a higher body mass index or other adiposity measures, but the statistical significance was not sustained when pooling their data together. Through the estimates provided in the present review, it is noted that CRP tends to be more elevated in female patients with RA that have a higher BMI. However, this association is not present in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRP tends to be elevated in female patients with RA that have a higher BMI. Further research is required to assess this possible sex\u2010related difference and to aid shared decision\u2010making in order to avoid over\u2010treatment and increased burden in patients with obesity and RA.<\/jats:p><jats:p>PROSPERO registration number: CRD42022314580.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1756-185x.14948","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T12:24:12Z","timestamp":1698409452000},"page":"2498-2508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of obesity and overweight on C\u2010reactive protein concentrations and disease activity in rheumatoid arthritis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"Diana E.","family":"Flores\u2010Alvarado","sequence":"first","affiliation":[{"name":"Rheumatology Division, Department of Internal Medicine University Hospital \u201cDr. Jos\u00e9 E. 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