{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:29:56Z","timestamp":1786562996577,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C) is a rare and serious systemic inflammatory disorder that occurs following a severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. This study aims to investigate the clinical manifestations, risk factors associated with pediatric intensive care unit (PICU) admission, and outcome among children with MIS\u2010C in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted among pediatric patients diagnosed with MIS\u2010C between June 2022 and February 2023 at Chang Gung Memorial Hospital, Linkou, Taiwan. Data on demographics, clinical features, laboratory findings, treatment modalities, and outcomes were collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight MIS\u2010C patients, including 9 boys and 19 girls, with an average age of 5.3\u2009\u00b1\u20093.8\u2009years old, were enrolled. Most of the cases (78.6%) were diagnosed following the first pandemic wave of COVID\u201019 in Taiwan. The leading clinical manifestations observed were fever (100%), skin rash (64.3%), tachycardia (46.4%), and vomiting (46.4%). Nine patients (32.1%) were admitted to the PICU due to hypotension or neurological manifestations. Higher levels of band\u2010form white blood cells, procalcitonin, ferritin, d\u2010dimer, prothrombin time, NT\u2010proBNP, and lower platelet levels on arrival were associated with PICU admission (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20093.9\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      ,9\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      , 4\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ,1\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      , 5\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      , 4.1\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      , and 3.4\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      , respectively). Arrhythmia in one case (3.5%) and coronary artery abnormalities, including dilatation in two cases (7.1%) and small aneurysms in one case (3.5%) were identified. Regardless of ICU admission, no patients experienced systolic dysfunction or mortality following treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MIS\u2010C cases in Taiwan have a favorable outcome. Although one\u2010third of the patients required PICU admission, none of the MIS\u2010C cases resulted in severe cardiovascular morbidity or mortality. This study provides valuable insights into the clinical manifestations and outcomes associated with PICU admission in children with MIS\u2010C in Taiwan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14970","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T06:49:52Z","timestamp":1699598992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical manifestations and outcomes associated with\n                    <scp>PICU<\/scp>\n                    admission in children with multisystem inflammatory syndrome in Taiwan: A retrospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Chi\u2010Teng","family":"Tseng","sequence":"first","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainn\u2010Jim","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan city Taiwan"},{"name":"Division of Pediatric Critical Care Medicine, Department of Pediatrics Chang Gung Memorial Hospital at Linkou  Taoyuan city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan city Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan city Taiwan"},{"name":"Department of Pediatrics New Taipei Municipal TuCheng Hospital  New Taipei city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Hsun","family":"Chiu","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan city Taiwan"},{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics Chang Gung Memorial Hospital  Taoyuan city Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan city Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"157","article-title":"WHO declares COVID\u201019 a pandemic","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Biomed"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-320338"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30651-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.0630"},{"key":"e_1_2_11_9_1","volume-title":"CDC and WHO Case Definitions of Multisystem Inflammatory Syndrome in Children","author":"Mary Beth F","year":"2023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40124-022-00264-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.16420"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmab104"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00050-X"},{"key":"e_1_2_11_14_1","unstructured":"CECC confirms 94 855 more COVID\u201019 cases including 94 808 domestic cases and 47 imported cases.2022. 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