{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:23:26Z","timestamp":1792700606048,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies have demonstrated the association of hyperuricemia with hypertension, metabolic syndrome, cardiovascular disease, and chronic renal disease. Although Western medicine presents promising effects for treating hyperuricemia and gout, identifying a safe and effective alternative to traditional Chinese medicine (TCM) for treating hyperuricemia is essential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of TCM formulas, \u201cWu\u2010Ling San\u201d and \u201cYin Chen Wu\u2010Ling San,\u201d in patients with hyperuricemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blinded, placebo\u2010controlled clinical trial in adults with hyperuricemia was conducted. Sixty patients with serum urate level higher than 8\u2009mg\/dL were enrolled in the study. Patients were then randomized into three arms: \u201cWu\u2010Ling San,\u201d \u201cYin Chen Wu\u2010Ling San,\u201d and placebo for 4\u2009weeks. Efficacy and safety were evaluated at weeks 2, 4, and 8. Primary and secondary endpoints were set to evaluate the serum urate concentration and related indicators at weeks 2, 4, and 8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were observed among the three arms in terms of the serum urate level (&lt;6\u2009mg\/dL) at week 4. The serum urate level was lower in the \u201cYin Chen Wi\u2010Ling\u201d arm at week 8 (8.1\u2009mg\/dL vs. 9.1\u2009mg\/dL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.034). The serum urate levels were significantly different in both the \u201cWu\u2010Ling San\u201d and \u201cYin Chen Wu\u2010Ling San\u201d arms from those at the baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two TCM formulas were found to be relatively safe for the short\u2010term treatment of the patients with hyperuricemia. No statistically significant difference was observed in reaching the target\u2013serum urate level &lt;6\u2009mg\/dL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14986","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T04:10:40Z","timestamp":1701144640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Traditional Chinese medicine in the treatment of patients with hyperuricemia: A randomized\n                    <scp>placebo\u2010controlled double\u2010blinded<\/scp>\n                    clinical trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-0903","authenticated-orcid":false,"given":"Pui\u2010Ying","family":"Leong","sequence":"first","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Chung Shan Medical University Hospital  Taichung Taiwan"},{"name":"PhD Program of Business Feng\u2010Chia University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang\u2010Hsi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-5635","authenticated-orcid":false,"given":"Shuo\u2010Yan","family":"Gau","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Institute of Medical Education Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical 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