{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:15:35Z","timestamp":1787501735929,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To elucidate the efficacy and safety of aggressive multi\u2010combination therapy with mycophenolate mofetil, rituximab, and plasma exchange or polymyxin B immobilized fiber column direct hemoperfusion followed by conventional therapy with corticosteroids, calcineurin inhibitors, and intravenous pulse cyclophosphamide in patients with rapidly progressive interstitial lung disease (RPILD) with anti\u2010melanoma differentiation\u2010associated gene 5 (MDA5)\u2010antibody\u2010positive dermatomyositis (DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 23 patients with anti\u2010MDA5 antibody\u2010positive DM\u2010RPILD were enrolled, with nine patients in Group A (treated conventionally before March 2015) and 14 patients in Group B (received aggressive treatment after April 2015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pretreatment severity of interstitial lung disease (ILD) did not differ between the two groups. However, Group B exhibited a higher cumulative survival rate at 48\u2009weeks than Group A (64.3% vs. 33.3%). The corticosteroid dose, divided by the initial dose at 3\u2009months and 12\u2009months, was significantly lower in Group B than in Group A (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.046 and .026, respectively). Among the ILD\u2010related deaths in Group B, there was a tendency toward a higher proportion of males and more severe ILD. The incidence of infection did not differ between the groups, but leukopenia was more common in Group B.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This aggressive multi\u2010combination therapy may improve the survival outcome of patients with anti\u2010MDA5 antibody\u2010positive DM\u2010RPILD. However, careful management of complications, such as opportunistic infections and leukopenia, is essential. Future refinement through longitudinal investigations tracking the long\u2010term efficacy, safety, and cost\u2010effectiveness of this treatment strategy is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.14999","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T12:01:01Z","timestamp":1702036861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Aggressive multi\u2010combination therapy for anti\u2010MDA5 antibody\u2010positive dermatomyositis\u2010rapidly progressive interstitial lung disease"],"prefix":"10.1111","volume":"27","author":[{"given":"Kenichiro","family":"Hata","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (IV), Division of Rheumatology Osaka Medical and Pharmaceutical University  Takatsuki 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