{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:45:51Z","timestamp":1789343151496,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J of Rheum Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the association between antirheumatic drugs and of the risk of nonalcoholic fatty liver disease (NAFLD) in a nationwide rheumatoid arthritis (RA) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using claim data from the 2000\u20132020 National Health Insurance Research Database, we identified 21\u2009457 incident patients with RA from 2002 to 2020 without prior liver diseases. A time\u2010varying multivariable Cox regression model was applied to estimate for the association of NAFLD with the use of antirheumatic drugs after adjusting potential confounders, show as adjusted hazard ratios (aHRs) with 95% confidence interval (CIs). Subgroup analyses were conducted based on age\u2010, sex\u2010, and obesity\u2010related comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariable time\u2010dependent Cox regression analyses showed that defined daily dose (DDD) of NSAID (aHR, 1.03; 95% CI: 1.02\u20131.05) and prednisolone equivalent dose &gt;5\u2009mg\/day (aHR, 2.39; 95% CI: 1.85\u20133.09) were risk factors of NAFLD in patients with RA, while prednisolone equivalent dose \u22645\u2009mg\/day (aHR of 0.53; 95% CI: 0.40\u20130.71) and HCQ use (aHR of 0.75; 95% CI: 0.60\u20130.93) were associated with a decreased risk of NAFLD. In addition, a history of hospitalizations, number of outpatient visits, age, male, and leflunomide use were associated with the development of NAFLD in some subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals that NSAID use and prednisolone equivalent dose &gt;5\u2009mg\/day were associated with an increased risk of NAFLD in patients with RA, while the use of HCQ and prednisolone equivalent dose \u22645\u2009mg\/day decreased the risk of NAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1756-185x.15003","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T05:17:51Z","timestamp":1702271871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antirheumatic drugs and the risk of nonalcoholic fatty liver disease in patients with rheumatoid arthritis: A nationwide, population\u2010based cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9133-568X","authenticated-orcid":false,"given":"Chia\u2010Chu","family":"Meng","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-2235","authenticated-orcid":false,"given":"Der\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Program in Translational Medicine, Rong Hsing Research Center for Translational Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"Rheumatology and Immunology Center China Medical University Hospital  Taichung Taiwan"},{"name":"College of Medicine China Medical University  Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung 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Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-4587","authenticated-orcid":false,"given":"Hsin\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"},{"name":"Division of General Medicine, Department of Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Program in Translational Medicine and Rong Hsing Research Center for Translational Medi\u2010cine National Chung Hsing University  Taichung Taiwan"},{"name":"Big Data Center National Chung Hsing University  Taichung 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