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About 4.7% of the world's population suffers from generalized pain and hypersensitivity, in addition to a wide range of physical and psychological symptoms. The etiopathogenesis of this disease is multifactorial, which makes its diagnosis and treatment challenging. Recently, the increase in the number of studies on microbiota has provided new data that can help to understand the onset and development of FM. An updated systematic review of the causes of FM has been carried out in this work. Particularly in the last decade, research has focused on the gut\u2013brain axis, which has emerged as a crucial mechanism for microbiota\u2010host crosstalk. In FM patients, quantitative imbalances of the intestinal microbiota (dysbiosis) and bacterial metabolites with differential relative abundance have been found, especially short\u2010chain fatty acids and lipopolysaccharides. Furthermore, the microbiota has been found to indirectly influence host neurotransmitter mechanisms, mainly through the serotonin precursor, glutamate, and gamma\u2010aminobutyric acid. Thus, all these mechanisms and their influence on the etiopathogenesis of FM are discussed in this review.<\/jats:p>","DOI":"10.1111\/1756-185x.15021","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T23:40:50Z","timestamp":1706312450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5380-9802","authenticated-orcid":false,"given":"Juan Francisco","family":"Palma\u2010Ord\u00f3\u00f1ez","sequence":"first","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental Hospital Universitario Virgen de Valme  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-9594","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Moreno\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Citolog\u00eda e Histolog\u00eda Normal y Patol\u00f3gica Universidad de Sevilla  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-1712","authenticated-orcid":false,"given":"Jorge Antol\u00edn","family":"Ram\u00edrez\u2010Tejero","sequence":"additional","affiliation":[{"name":"Pronacera Therapeutics S.L.  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